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- Table of Contents
Crlf2 Antibodies
AND Crlf2 ELISA kits, Crlf2 Proteins
Many biological assays use antibodies to detect Crlf2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Crlf2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Crlf2 antibodies...
Designing a Western blot for Crlf2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CRLF2 Western Blot GuideCrlf2 Infographic by Boster Bio
All Crlf2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$750
Cat # EK1288
96 wells/kit, with removable strips.
Cat # EK1288
96 wells/kit, with removable strips.
Mouse
ELISA
$750
Cat # EK1665
96 wells/kit, with removable strips.
Cat # EK1665
96 wells/kit, with removable strips.
Crlf2 Overview
Facts about Cytokine receptor-like factor 2.
Cytokine receptor-like factor 2 (Crlf2)
Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5.
Also activates JAK2. Implicated in the development of the hematopoietic system.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Crlf2 |
| Uniprot: | Q8CII9 |
| Entrez: | 57914 |
Family
| Belongs to: |
|---|
| type I cytokine receptor family |
Alternative Names
CRL2; CRL2cytokine receptor CRL2 precusor; CRLF2; CRLF2Y; CRLM-2; Cytokine receptor-like 2; cytokine receptor-like factor 2; ILXR; IL-XR; P2RY8/CRLF2 fusion; PCOR1; Thymic stromal lymphopoietin protein receptor; thymic stromal lymphopoietin receptor; thymic stromal-derived lymphopoietin receptor; TSLP R; TSLP receptor; TSLPR
Molecular Weight
Mass (kDA):
37.762 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 5|5 F |
| Sequence: | 5; |
Tissue Specificity
High level of expression in liver, lung and testis. Also expressed in heart, brain, spleen, thymus and bone marrow. Highly expressed in progenitors and myeloid cells. Isoform 2 is expressed in primary hemotopoietic cells.
Diseases
- Leukemia
- Acute Lymphocytic Leukemia
- Inflammation
- Asthma
- Precursor B-cell Lymphoblastic Leukemia-lymphoma
- Dermatitis, Atopic
- Dermatitis
- Down Syndrome
- Chromosomal Translocation
- Janiceps
- Malignant Neoplasms
- L1 Acute Lymphoblastic Leukemia
- Allergy
Pathways
- Pathogenesis
- Cell Proliferation
- Cytokine Production
- Immune Response
- Cell Development
- T Cell Homeostasis
- Localization
- Cell Adhesion
- Cell Activation
- Cytokine Secretion
- Inflammatory Response
- Sensitization
- Notch Signaling Pathway
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Crlf2
bosterbio.com/bosterbio-gene-info-cards/Crlf2
References
PMID: 10872831 by Hiroyama T., et al. Molecular cloning and characterization of CRLM-2, a novel type I cytokine receptor preferentially expressed in hematopoietic cells.
PMID: 10733486 by Fujio K., et al. Molecular cloning of a novel type I cytokine receptor similar to the common gamma chain.