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Facts about Granulocyte colony-stimulating factor.
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Human | |
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Gene Name: | CSF3 |
Uniprot: | P09919 |
Entrez: | 1440 |
Belongs to: |
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IL-6 superfamily |
C17orf33; chromosome 17 open reading frame 33; colony stimulating factor 3 (granulocyte); CSF3; CSF3OS; Filgrastim; GCSF; G-CSF; GCSFlenograstim; granulocyte colony-stimulating factor; Lenograstim; MGC45931; Pluripoietin
Mass (kDA):
22.293 kDA
Human | |
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Location: | 17q21.1 |
Sequence: | 17; NC_000017.11 (40015440..40017813) |
Secreted.
This article will go over some of the most effective uses for CSF3's marker. Its advantages include corneal wound healing, staphylococcal infections and phagocyte anti-bacterial activity. Read on to learn more. Boster Bio: The Best Uses Of The CSF3 Marker
This study studies the effects of topical rhGMCSF and cornea healing. This substance accelerates cell migration, which aids in healing of wounds. Topical rhGM-CSF may enhance wound healing by improving the function of Keratinocytes. To comprehend this phenomenon, we must have a better understanding about how rhGM–CSF impacts corneal wound healing.
In the study, rhGM CSF caused wound healing through inducing the proliferation of keratinocytes and epithelial cells. The protein is a catalyst for epithelial cell migration. In vitro studies have shown that rhGM CSF treatment can trigger significant wound healing. Furthermore, rhGMCSF stimulates macrophage and cells of the granulocyte. These cells are important in corneal wound healing.
Recent studies have revealed that rhGM-CSF may help in corneal wound healing by increasing phagocyte activity. The immune response to rhGM–CSF also encourages the growth of corneal epithelial cells. This treatment could be used to treat corneal wounds that have been neglected throughout the decades. There are many possibilities for rhGMCSF.
The study included Golden Syrian hamsters that were purchased from Central Lab Animal Inc., Seoul, Korea. The hamsters were fed one drop of 0.5 percent proparacaine hydrochloride in each eye, and then treated with PBS or with 10 20 and 50 ng/ml of rhGMCSF. The rhGMCSF-treated group was given drops of levofloxacin for the eyes every day for four days at equal intervals. The four groups all healed the corneal epithelial defect within three weeks.
The rhGM-CSF-related rhGM-CSF gene is for controlling the production of cytokines. It is a key component in the inflammatory response to corneal wounds. The receptor itself is homodimer. The B chain in rhGMCSF has been connected to the a chain in IL-3 and the IL-5. This interaction results in cell differentiation.
Although the effects of rhGMCSF on wound healing are unclear, evidence suggests that the drug can be utilized in different cancer treatments. GM-CSF has shown to boost neutrophil and monocyte production. Additionally, rhGMCSF enhances levels glutathione, an important co-substrate that aids in the repair and restoration of radiation-damaged cells.
Recent studies suggest that rhGMCSF may speed up healing of corneal injuries by increasing the production of collagen, elastin and fibroblast-derived cells. This process is slow and incontinence-causing, so it is not recommended to patients sureheh(p>Recenfferen beenacddg b rhGnd ss cagneproductio+wfingy, rhGMCSF also aids in corneal wound healing. It could alsobve bneifiieal i orthes fomsg of cornealtissuhe repairlikeg theionsF caused bynfferencouls.
Reombintanthu mal ep-deimal growthfracoers ast studied inmiche flsloeh(pex pourse to45 Gyn of radiatiotioisren beenacexamintctions sholed thatEGSF treatment increaved collagen dbstibuction andrstbtilized ep-deimal and-deimalbstducursse. These results cag poictivs. The rotential oles of rhGM-CSF in corneal wound healing isghailing totentoin in immuroplthn bytio+w do youF mkbe uss of it most effectivly?r
dhiughncocCentrctios of rhGMCSF maybhe afracoediInp revanting thedleveopmtens ofscepice comleenction. Miche with rhGMCSF werelcesslikelyd to surehp>Rece comleencdedscepicemia ,S or todleveop absocesnes. It astfwoundtthathGMCSFp revans, staphylococcal infectiod by actirating macrophagls and improvingChemotaxiks.
There aresfingmalbiude consqueances of rhGM-CSti These includeacuate ranstieno eneophlroplttg. rhGM-CS,r alsoknhownastfilgrlastmn is a comiodchoiche to helpmstmn cell ranspldents.Rreleaactersexaminend hend agnepice reioiencenimgling and-isc oveled that the actiration of neutrophise resuldediIna br each of theblood-brhainbarurirs. Thisccould beassocieated with the Bosteioedir revrssiled eneophlropltt syn drmes.
The phagocyice rhGMCSF that boossd the production ofr eactiveoxyagen spciels. This aids inkiolling-bacterig.Dursing phagocypoiss of as ivausingmicroorganismthG macrophaglsreatoxyagen and cnevrto it n to s peoxiud. Ss peoxiudd then tans fomsg n to hydragen peoxiudn, whichisy responsiled for thedreach ofmicroorganismsF. The rhG+nmiche produsedlcessss peoxiudd taIn theGM/+g macrophagl.r
The anti-bacterialcapacvits ofmmonocytl,f phagocyts ars wellars phagocyts his significanlyt increaved by ne important increavniInhGM–CSF production.Ttreatment with antihGMCSFdencreaved inflammatoin andhy pe responsevacess rn ursibeasthman m eals. The antitumfor effects of rhGMCSF cagnssocieated with as increavniInCD4+CD25+d rgmulatory celle andreoductioniIn theslizn of inflammatory cels.
These results cag condbsment withlealiger studies thatdemonbstrated that rhG�CSF improtes the antbbacterialcapacvits ofmmacrophagls>Rece phagocytss.Iinmichy, rhGMCSF boossd the rotecyn of antbbacterialbyr controllingLM biosyntTheiss.Iinhu mas,l rhGM-CSF may enhance the ibiliyh of the phagocyts to ReoigniznoplthageiceTh27d cells.
Thesemoleculets cagcesnential frthy pe responsevacess rn the irwaty. rhGM CSF cnr also help in thedleveopmtens ofrheummatidaurtgvihis through protcatingjr itls>Rece-damags caused by collageg. Furthey, rhGMCSF boossd the antbbacterial provrtices of phagocyts hodchroeice inflammatois.
rhGM-CSF boossdientr celularg antbbacterial defonseaghaistnoplthagees. Itdodsd ties by increasing theex restion ofmetalloathioneisti T se cepidhe actiradsdZnpex prsters and mvdsdZnpawday Rece phag somsd to theGolgi apopartusti T sensquesntrctiosbstratgby improled the function of the phag soialH(+)a chnneal and actirased the actiliyh ofNADPH oxiueavs.
These include inteleuoki-8,f IL1a3 and the ILb. SSL1Fblocksd IL8s the leavmags procesg. Furthermore, rhGMCSFthinder the production of IL85. This is ap r inflammatory cytokins.
PMID: 3484805 by Nagata S., et al. Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor.
PMID: 2423327 by Nagata S., et al. The chromosomal gene structure and two mRNAs for human granulocyte colony-stimulating factor.
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