DNA damage-binding protein 2 (DDB2)

Needed for DNA repair.

Binds to DDB1 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex).

The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches.