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- Table of Contents
DLD Antibodies
AND DLD ELISA kits, DLD Proteins
Many biological assays use antibodies to detect DLD, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DLD in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DLD antibodies...
Designing a Western blot for DLD? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the DLD Western Blot GuideDLD Infographic by Boster Bio
All DLD Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, IHC-F, ICC, WB
$370
Cat # PA1463
100 μg/vial
Cat # PA1463
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9579
100 μg/vial
Cat # PB9579
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00870-2
100 μl/vial
Cat # M00870-2
100 μl/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M00870
100 µl
Cat # M00870
100 µl
Dog, Human, Monkey, Mouse, Rat
Flow Cytometry, IF, WB
$523
Cat # M00870-1
100 µl
Cat # M00870-1
100 µl
Human
$628
Cat # LS001738
20 µg, 100 µg
Cat # LS001738
20 µg, 100 µg
Enzyme Activity, SDS-PAGE
$243
Cat # PROTP09622
Starting from 20ug
Cat # PROTP09622
Starting from 20ug
DLD Overview
Facts about Dihydrolipoyl dehydrogenase, mitochondrial.
Dihydrolipoyl dehydrogenase, mitochondrial (DLD)
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 part of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complicated ) (PubMed:15712224, PubMed:16442803, PubMed:16770810, PubMed:17404228, PubMed:20160912, PubMed:20385101). The 2-oxoglutarate dehydrogenase complex is mostly active in the mitochondrion (PubMed:29211711).
A fraction of this 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: partners with KAT2A on chromatin and supplies succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). In monomeric form may have added moonlighting function as serine protease (PubMed:17404228).
Gene Information
| Human | |
|---|---|
| Gene Name: | DLD |
| Uniprot: | P09622 |
| Entrez: | 1738 |
Family
| Belongs to: |
|---|
| class-I pyridine nucleotide-disulfide oxidoreductase family |
Alternative Names
2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex); branched chain keto acid dehydrogenase complex; Diaphorase; dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex; Dihydrolipoamide Dehydrogenase; dihydrolipoamide dehydrogenasemitochondrial; DLD; DLDD; DLDH; E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex; E3; EC 1.8.1; EC 1.8.1.4; GCSL; Glycine cleavage system L protein; glycine cleavage system protein L; LAD; Lipoamide Dehydrogenase; lipoamide reductase; lipoyl dehydrogenase; PHE3
Molecular Weight
Mass (kDA):
54.177 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q31.1 |
| Sequence: | 7; NC_000007.14 (107891107..107921198) |
Subcellular Localizations
Mitochondrion matrix. Nucleus. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation.
Diseases
- Language Development Disorders
- Language Disorders
- Autistic Disorder
- Lung Diseases
- Malignant Tumor Of Colon
- Neoplasms
- Malignant Neoplasms
- Hypertensive Disease
- Carcinoma
- Malnutrition
- Acidosis
- Colonic Neoplasms
Interacting Proteins
- PDHX
- PRDX6
- YWHAE
Pathways
- Pathogenesis
- Localization
- Transport
- Cell Growth
- Fermentation
- Angiogenesis
- Regeneration
- Acrosome Reaction
- Electron Transport
- Hypersensitivity
- Neurogenesis
- Oxidative Phosphorylation
- Methylation
PTMs
- Oxidation
- Cleavage
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DLD
bosterbio.com/bosterbio-gene-info-cards/DLD
References
PMID: 3693355 by Otulakowski G., et al. Isolation and sequence determination of cDNA clones for porcine and human lipoamide dehydrogenase. Homology to other disulfide oxidoreductases.
PMID: 3278312 by Pons G., et al. Cloning and cDNA sequence of the dihydrolipoamide dehydrogenase component human alpha-ketoacid dehydrogenase complexes.