Dihydrolipoyl dehydrogenase, mitochondrial (DLD)

Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 part of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complicated ) (PubMed:15712224, PubMed:16442803, PubMed:16770810, PubMed:17404228, PubMed:20160912, PubMed:20385101). The 2-oxoglutarate dehydrogenase complex is mostly active in the mitochondrion (PubMed:29211711).

A fraction of this 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: partners with KAT2A on chromatin and supplies succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). In monomeric form may have added moonlighting function as serine protease (PubMed:17404228).