Disks large homolog 2 (DLG2)

Required for understanding of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord.

Interacts with the cytoplasmic tail of NMDA receptor subunits in addition to inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses.