DPYD Antibodies

AND DPYD ELISA kits, DPYD Proteins

Many biological assays use antibodies to detect DPYD, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DPYD in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DPYD antibodies...

We validate the specificity of these antibodies to DPYD by testing them on tissues known to express DPYD positively and negatively. Browse below to find the DPYD antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DPYD Infographic by Boster Bio

All DPYD Products

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Anti-DPYD Antibody Picoband®

7 Q&As

Western blot analysis of DPYD using anti-DPYD antibody (PA1761)

Flow Cytometry analysis of HepG2 cells using anti-DPYD antibody (PA1761)

Human, Mouse, Rat

Flow Cytometry, WB

$370
Cat # PA1761
100 μg/vial

Anti-DPYD Antibody Picoband®

Western blot analysis of DPYD using anti-DPYD antibody (A01749)

Human, Mouse, Rat

ELISA, WB

$370
Cat # A01749
100 μg/vial

Anti-DPYD Antibody

Western Blot analysis of HepG2 cells using DPYD Polyclonal Antibody

Western blot analysis of lysate from HepG2 cells, using DPYD Antibody

Immunohistochemical analysis of paraffin-embedded mouse-lung, antibody was diluted at 1:100

Human, Mouse, Rat

ELISA, IF, IHC, WB

$380
Cat # A01749-1
100ul

Anti-DPYD Rabbit Monoclonal Antibody

Western blot analysis of DPYD expression in HeLa cell lysate

Human

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M01749
100 μl/vial

Anti-Zebrafish DPYD Antibody Picoband®

Western blot analysis of DPYD using anti-DPYD antibody (AZQ6NYG8)

IHC analysis of DPYD using anti-DPYD antibody (AZQ6NYG8)

Zebrafish

IHC, WB

$470
Cat # AZQ6NYG8
100 μg/vial

DPYD Overview

Facts about Dihydropyrimidine dehydrogenase [NADP(+)].

DPYD 3D structure. Source: alphafold

Dihydropyrimidine dehydrogenase [NADP(+)] (DPYD)

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.

Also involved the degradation of the chemotherapeutic drug 5-fluorouracil. .

Gene Information

Human
Gene Name:	DPYD
Uniprot:	Q12882
Entrez:	1806

Family

Belongs to:

dihydropyrimidine dehydrogenase family

Alternative Names

DHP; DHPDHASE; dihydropyrimidine dehydrogenase [NADP+]; dihydropyrimidine dehydrogenase; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase; DPDMGC132008; EC 1.3.1.2; MGC70799

Molecular Weight

Mass (kDA):
111.401 kDA

Genomic Context


Human

Location:	1p21.3
Sequence:	1; NC_000001.11 (97077743..97921059, complement)

Tissue Specificity

Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.

Subcellular Localizations

Cytoplasm.

Diseases

Malignant Neoplasms
Neoplasms
Dihydropyrimidine Dehydrogenase Deficiency
Colorectal Neoplasms
Colorectal Cancer
5,10-methylenetetrahydrofolate Reductase Deficiency
Carcinoma
Adenocarcinoma
Mucositis
Diarrhea
Stomach Neoplasms
Medication Reaction
Malignant Neoplasm Of Breast

Malignant Neoplasm Of Stomach
Rheumatoid Arthritis
Arthritis
Malignant Tumor Of Colon
Pain
Osteoporosis
Neoplasm Metastasis

Interacting Proteins

GOPC
LXN

Pathways

Bone Resorption
Excretion
Methylation
Dna Repair
Cell Cycle
Pathogenesis
Dna Methylation
Menopause
Translation
S Phase
Transport
Immune Response
Neurogenesis

Response To Drug
Demethylation
Flight
Sensitization
Response To 5-fluorouracil
Drug Transport
Cell Death

PTMs

Methylation

Demethylation

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DPYD

References

PMID: 8083224 by Yokota H., et al. cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria.

PMID: 9135003 by Johnson M.R., et al. Structural organization of the human dihydropyrimidine dehydrogenase gene.