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Transcription factor E2F2 Antibodies
AND E2F2 ELISA kits, Transcription factor E2F2 Proteins
Many biological assays use antibodies to detect Transcription factor E2F2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcription factor E2F2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcription factor E2F2 antibodies...
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E2F2 Infographic by Boster Bio
All E2F2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$370
Cat # PA1810
100 μg/vial
Cat # PA1810
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # M02896-1
100 μl/vial
Cat # M02896-1
100 μl/vial
E2F2 Overview
Facts about Transcription factor E2F2.
Transcription factor E2F2 (E2F2)
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a variety of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase.
E2F2 binds specifically to RB1 in a cell-cycle dependent manner. .
Gene Information
| Human | |
|---|---|
| Gene Name: | E2F2 |
| Uniprot: | Q14209 |
| Entrez: | 1870 |
Family
| Belongs to: |
|---|
| E2F/DP family |
Alternative Names
E2F transcription factor 2; E2F2; E2F-2; E2F-2transcription factor E2F2
Molecular Weight
Mass (kDA):
47.506 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.12 |
| Sequence: | 1; NC_000001.11 (23505696..23531250, complement) |
Tissue Specificity
Highest level of expression is found in placenta, low levels are found in lung. Found as well in many immortalized cell lines derived from tumor samples.
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Retinoblastoma
- Cell Transformation, Neoplastic
- Hyperplasia
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Malignant Neoplasm Of Ovary
- Ovarian Neoplasm
- Osteosarcoma
- Autoimmunity
Interacting Proteins
- RB1
Pathways
- Cell Cycle
- Cell Proliferation
- S Phase
- Cell Growth
- Dna Replication
- Cell Division
- Cell Cycle Arrest
- Cell Death
- Oncogenesis
- Senescence
- Dna Repair
- Regeneration
- Mitosis
PTMs
- Phosphorylation
- Methylation
- Acetylation
Research Areas
- Cell Cycle and Replication
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/E2F2
bosterbio.com/bosterbio-gene-info-cards/E2F2
References
PMID: 8246995 by Ivey-Hoyle M., et al. Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F.
PMID: 16360038 by Rubin S.M., et al. Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.
1 Publications of Boster Transcription factor E2F2 Antibodies & ELISA Kits
- PubMed ID: 26378521, GCN5 Potentiates Glioma Proliferation and Invasion via STAT3 and AKT Signaling P...
*More publications can be found for each product on its corresponding product page