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Transcription factor E2F5 Antibodies
AND E2F5 ELISA kits, Transcription factor E2F5 Proteins
Many biological assays use antibodies to detect Transcription factor E2F5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Transcription factor E2F5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Transcription factor E2F5 antibodies...
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E2F5 Infographic by Boster Bio
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E2F5 Overview
Facts about Transcription factor E2F5.
Transcription factor E2F5 (E2F5)
Transcriptional activator that binds to E2F sites, these websites are found in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor- initiated signal transduction.
It's likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: jointly with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | E2F5 |
| Uniprot: | Q15329 |
| Entrez: | 1875 |
Family
| Belongs to: |
|---|
| E2F/DP family |
Alternative Names
E2F transcription factor 5, p130-binding; E2F-5; transcription factor E2F5
Molecular Weight
Mass (kDA):
37.61 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q21.2 |
| Sequence: | 8; NC_000008.11 (85177154..85214518) |
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Retinoblastoma
- Malignant Neoplasms
- Carcinoma
- Hyperplasia
- Malignant Neoplasm Of Breast
- Growth Arrest
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Ovary
- Malignant Paraganglionic Neoplasm
- Melanoma
- Ovarian Neoplasm
Pathways
- Cell Cycle
- Cell Proliferation
- S Phase
- Cell Growth
- Cell Cycle Arrest
- Localization
- Cell Death
- G1 Phase
- Pathogenesis
- Regeneration
- Dna Replication
- Regulation Of Gene Expression
- Cell Differentiation
PTMs
- Phosphorylation
- Cleavage
- Dephosphorylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/E2F5
bosterbio.com/bosterbio-gene-info-cards/E2F5
References
PMID: 8589754 by Itoh A., et al. Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors.
PMID: 7760804 by Hijmans E.M., et al. E2F-5, a new E2F family member that interacts with p130 in vivo.