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Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC.
|protein kinase superfamily|
|Sequence:||7; NC_000007.14 (143390813..143408865, complement)|
Overexpressed in several carcinomas.
Cell membrane; Single-pass type I membrane protein.