Ephrin type-A receptor 5 (EPHA5)

Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands living on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is known as forward signaling while the signaling pathway downstream of the ephrin ligand is known as reverse signaling.

One of GPI-anchored ephrin-A ligands, EFNA5 most likely constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways.