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- Table of Contents
HGS Antibodies
AND HGS ELISA kits, HGS Proteins
Many biological assays use antibodies to detect HGS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HGS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HGS antibodies...
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HGS Infographic by Boster Bio
All HGS Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1272
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1272
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2293
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2293
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01174-1
100 μg/vial
Cat # A01174-1
100 μg/vial
Human, Mouse, Rat
IF, WB
$523
Cat # M01174
100 µl
Cat # M01174
100 µl
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M01174-1
100 μg/vial
Cat # M01174-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01174-2
100 μg/vial
Cat # M01174-2
100 μg/vial
HGS Overview
Facts about Hepatocyte growth factor-regulated tyrosine kinase substrate.
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS)
Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA indicating upon stimulation by IL-2 and GM-CSF.
Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May focus ubiquitinated receptors in clathrin-coated regions.
Gene Information
| Human | |
|---|---|
| Gene Name: | HGS |
| Uniprot: | O14964 |
| Entrez: | 9146 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FLJ39878; hepatocyte growth factor-regulated tyrosine kinase substrate; Hrs; HRSFLJ11421; human growth factor-regulated tyrosine kinase substrate; Protein pp110; Vps27; ZFYVE8
Molecular Weight
Mass (kDA):
86.192 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q25.3 |
| Sequence: | 17; NC_000017.11 (81684011..81702121) |
Tissue Specificity
Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes.
Subcellular Localizations
Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Endosome, multivesicular body membrane; Peripheral membrane protein. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malnutrition
- Kidney Failure, Chronic
- Kidney Diseases
- Carcinoma
- Inflammation
- Diabetes Mellitus
- Neoplasm Metastasis
- Chronic Kidney Disease
- Ovarian Neoplasm
- Hepatoblastoma
- Infective Disorder
Pathways
- Hibernation
- Aging
- Localization
- Cell Growth
- Angiogenesis
- Pathogenesis
- Transport
- Endocytosis
- Glomerular Filtration
- Cell Migration
- Immune Response
- Oxidative Phosphorylation
- Interleukin-10 Production
PTMs
- Phosphorylation
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HGS
bosterbio.com/bosterbio-gene-info-cards/HGS
References
PMID: 9407053 by Asao H., et al. Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth.
PMID: 9630564 by Lu L., et al. Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17.