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In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors that, upon binding of a specific antigen, activate the clonal expansion and differentiation of B lymphocytes to immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector stage of humoral immunity, which causes the elimination of bound antigens (PubMed:22158414, PubMed:20176268).
|Sequence:||14; NC_000014.9 (105838401..105845677, complement)|
[Isoform 1]: Secreted.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.