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- Table of Contents
Integrin alpha-IIb Antibodies
AND ITGA2B ELISA kits, Integrin alpha-IIb Proteins
Many biological assays use antibodies to detect Integrin alpha-IIb, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Integrin alpha-IIb in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Integrin alpha-IIb antibodies...
Designing a Western blot for Integrin alpha-IIb? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ITGA2B Western Blot GuideITGA2B Infographic by Boster Bio
All ITGA2B Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$370
Cat # PB9647
100 μg/vial
Cat # PB9647
100 μg/vial
Human, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01102-1
100 µg/vial
Cat # A01102-1
100 µg/vial
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01102-3
100 μg
Cat # M01102-3
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01102-4
100 μg
Cat # M01102-4
100 μg
Human, Primate
Flow Cytometry, IHC-F
$301
Cat # M01102-1
0.1 mg
Cat # M01102-1
0.1 mg
ITGA2B Overview
Facts about Integrin alpha-IIb.
Integrin alpha-IIb (ITGA2B)
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide variety of ligands.
It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen.
Gene Information
| Human | |
|---|---|
| Gene Name: | ITGA2B |
| Uniprot: | P08514 |
| Entrez: | 3674 |
Family
| Belongs to: |
|---|
| integrin alpha chain family |
Alternative Names
CD41 antigen; CD41; CD41BHPA3; GP2B; GP2Bintegrin alpha-IIb; GPalpha IIb; GPIIb; GTA; HPA3; Integrin alpha 2b; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41); integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41B); ITGA2b; ITGAB; platelet fibrinogen receptor, alpha subunit; Platelet membrane glycoprotein IIb; platelet-specific antigen BAK
Molecular Weight
Mass (kDA):
113.377 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.31 |
| Sequence: | 17; NC_000017.11 (44372181..44389649, complement) |
Tissue Specificity
Isoform 1 and isoform 2 are expressed in platelets and megakaryocytes, but not in reticulocytes. Not detected in Jurkat, nor in U937 cell lines (PubMed:2351656). Isoform 3 is expressed in prostate adenocarcinoma, as well as in several erythroleukemia, prostate adenocarcinoma and melanoma cell lines, including PC-3, DU-145, HEL, WM983A, WM983B and WM35. Not detected in platelets, nor in normal prostate (at protein level) (PubMed:9809974).
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Thrombasthenia
- Hemorrhage
- Tissue Adhesions
- Von Willebrand Disease
- Thrombosis
- Bleeding Tendency
- Thrombus
- Myocardial Infarction
- Infarction
- 5,10-methylenetetrahydrofolate Reductase Deficiency
- Hereditary Diseases
- Inflammation
Interacting Proteins
- FLNA
- ITGB3
Pathways
- Platelet Aggregation
- Platelet Activation
- Hemostasis
- Secretion
- Pathogenesis
- Mrna Splicing
- Reverse Transcription
- Localization
- Coagulation
- Protein Phosphorylation
- Transport
- Clathrin-mediated Endocytosis
- Developmental Process
PTMs
- Phosphorylation
- Sulphation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGA2B
bosterbio.com/bosterbio-gene-info-cards/ITGA2B
References
PMID: 2439501 by Poncz M., et al. Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.
PMID: 2345548 by Frachet P., et al. GPIIb and GPIIIa amino acid sequences deduced from human megakaryocyte cDNAs.
3 Publications of Boster Integrin alpha-IIb Antibodies & ELISA Kits
- PubMed ID: 10.1038/s41598-017-12073-4, Thrombopoietic stimulating activity of rhTyrRS (Y341A)
- PubMed ID: -, Leila Revollo,Glenn Merrill-Skoloff,Karen De Ceunynck,James Dilks,Mattia Bordoli...
- PubMed ID: 28939876, Thrombopoietic stimulating activity of rhTyrRS (Y341A)
*More publications can be found for each product on its corresponding product page