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Product Info Summary
| SKU: | M01102-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Primate |
| Host: | Mouse |
| Application: | Flow Cytometry, IHC-F |
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Product info
Product Name
Anti-Hu CD41a Purified ITGA2B Monoclonal Antibody
SKU/Catalog Number
M01102-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Hu CD41a Purified ITGA2B Monoclonal Antibody (Catalog# M01102-1). Tested in Flow Cytometry, IHC-F application(s). This antibody reacts with Primate, Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-Hu CD41a Purified ITGA2B Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01102-1)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
HIP8
Isotype
Mouse IgG1
Immunogen
The antibody HIP8 reacts with an extracellular epitope on alpha (a) subunit of CD41 (heavy chain; 120 kDa). CD41 is mainly expressed on platelets and megakaryocytes. The antibody HIP8 blocks platelet aggregation and completely inhibits ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibits ristocetin- and thrombin-induced platelet activation. HIP8 is useful in the morphological and physiological studies o platelets and megakaryocytes.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
M01102-1 is reactive to ITGA2B in Human, Primate
Applications
M01102-1 is guaranteed for Flow Cytometry, IHC-F Boster Guarantee
Observed Molecular Weight
42 kDa
Calculated molecular weight
113.377kDa
Background of ITGA2B
CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow cytometry: 1-4 µg/ml
Validation Images & Assay Conditions
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Figure 1. Flow Cytometry validation of ITGA2B using Anti-Hu CD41a Purified ITGA2B Monoclonal Antibody (M01102-1).
Flow cytometry (surface staining) of human peripheral blood cells with anti-CD41a (HIP8) purifiedProtein Target Info & Infographic
Gene/Protein Information For ITGA2B (Source: Uniprot.org, NCBI)
Gene Name
ITGA2B
Full Name
Integrin alpha-IIb
Weight
113.377kDa
Superfamily
integrin alpha chain family
Alternative Names
CD41 antigen; CD41; CD41BHPA3; GP2B; GP2Bintegrin alpha-IIb; GPalpha IIb; GPIIb; GTA; HPA3; Integrin alpha 2b; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41); integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41B); ITGA2b; ITGAB; platelet fibrinogen receptor, alpha subunit; Platelet membrane glycoprotein IIb; platelet-specific antigen BAK ITGA2B BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93 integrin subunit alpha 2b integrin alpha-IIb|GPalpha IIb|alphaIIb protein|integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)|platelet fibrinogen receptor, alpha subunit|platelet glycoprotein IIb of IIb/IIIa complex|platelet membrane glycoprotein IIb|platelet-specific antigen BAK|protein phosphatase 1, regulatory subunit 93
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ITGA2B, check out the ITGA2B Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ITGA2B: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Hu CD41a Purified ITGA2B Monoclonal Antibody (M01102-1)
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