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- Table of Contents
Facts about N-lysine methyltransferase KMT5A.
H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.
Mouse | |
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Gene Name: | Kmt5a |
Uniprot: | Q2YDW7 |
Entrez: | 67956 |
Belongs to: |
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class V-like SAM-binding methyltransferase superfamily |
H4-K20-HMTase SETD8; H4K20-specific histone methyltransferase splice variant Set8b; Histone-lysine N-methyltransferase SETD8; KMT5A SET domain-containing protein 8; KMT5A; Lysine N-methyltransferase 5A; PR/SET domain containing protein 8; PR/SET domain-containing protein 07; PR/SET07; PRSET7; PR-Set7EC 2.1.1.43; SET domain containing (lysine methyltransferase) 8; SET07SET8H4-K20-specific histone methyltransferase; SET8
Mass (kDA):
38.845 kDA
Mouse | |
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Location: | 5|5 F |
Sequence: | 5; |
PMID: 23468428 by Serrano L., et al. The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation.