Kmt5a Antibodies

AND Kmt5a ELISA kits, Kmt5a Proteins

Many biological assays use antibodies to detect Kmt5a, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Kmt5a in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Kmt5a antibodies...

We validate the specificity of these antibodies to Kmt5a by testing them on tissues known to express Kmt5a positively and negatively. Browse below to find the Kmt5a antibody that suites your experiment. We have 7 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Kmt5a Infographic by Boster Bio

All Kmt5a Products

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Anti-KMT5A / SETD8 / Pr-SET7 Monoclonal Antibody

1 Q&As

Western blot analysis of KMT5A / SETD8 / Pr-SET7 expression in (1) 293T cell lysate; (2) NIH/3T3 cell lysate

Human, Mouse, Rat

Flow Cytometry, WB

$370
Cat # M05349
100 μl

Anti-SETD8 KMT5A Antibody

Western blot analysis of extracts of various cell lines, using KMT5A/KMT5A/SETD8 antibody at 1:1000 dilution

Immunofluorescence analysis of MCF-7 cells using KMT5A/KMT5A/SETD8 antibody

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A05349
100ul

Anti-KMT5A Antibody

Flow cytometric analysis of 293T cells with KMT5A antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black)

Human, Mouse

Flow Cytometry, WB

$405
Cat # A05349-1
100ul

Human KMT5A Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ9NQR1
Starting from 10ug

Anti-SET07 Antibody

All lanes :SET07 Antibody at 1:2000 dilutionLane 1: 293T whole cell lysateLane 2: 293 whole cell lysateLane 3: K562 whole cell lysateLysates/proteins at 20 µg per lane

(TOP)Negative control of hela cells without PE-conjugated goat anti-mouse lgG (whole molecule)

Human

IF, IHC-P, WB

$299
Cat # M05349-1
80 µl

KMT5A (NM_020382) Human Over-expression Lysate

Human

$628
Cat # LS387893
20 µg, 100 µg

Anti-SETD8/KMT5A antibody

Human, Mouse

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A05349-2
100 μl/vial

Kmt5a Overview

Facts about N-lysine methyltransferase KMT5A.

N-lysine methyltransferase KMT5A (Kmt5a)

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Especially monomethylates'Lys-20' of histone H4 (H4K20me1).

H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.

Gene Information

Mouse
Gene Name:	Kmt5a
Uniprot:	Q2YDW7
Entrez:	67956

Family

Belongs to:

class V-like SAM-binding methyltransferase superfamily

Alternative Names

H4-K20-HMTase SETD8; H4K20-specific histone methyltransferase splice variant Set8b; Histone-lysine N-methyltransferase SETD8; KMT5A SET domain-containing protein 8; KMT5A; Lysine N-methyltransferase 5A; PR/SET domain containing protein 8; PR/SET domain-containing protein 07; PR/SET07; PRSET7; PR-Set7EC 2.1.1.43; SET domain containing (lysine methyltransferase) 8; SET07SET8H4-K20-specific histone methyltransferase; SET8

Molecular Weight

Mass (kDA):
38.845 kDA

Genomic Context


Mouse

Location:	5\|5 F
Sequence:	5;

Diseases

Malignant Neoplasms
Neoplasms
Cell Transformation, Neoplastic
Genomic Instability
Cholangiocarcinoma
Malignant Neoplasm Of Breast
Malignant Neoplasm Of Brain
Mammary Neoplasms
Cytogenetic Abnormality
Malignant Paraganglionic Neoplasm
Brain Neoplasms
Neoplasm Metastasis
Ataxia

Aneuploidy
Neoplasm Invasiveness
Carcinoma
Carcinogenesis
Fetal Growth Retardation
Neoplasms, Glandular And Epithelial
Lymphoma

Pathways

Cell Cycle
Methylation
S Phase
Dna Replication
Mitosis
Cell Proliferation
Proteolysis
Dna Repair
Histone Modification
Regulation Of Gene Expression
Anaphase
Cell Division
Cell Differentiation

Prophase
Histone Methylation
Cell Adhesion
Gene Silencing
Lung Development
Liver Development
Hepatocyte Proliferation

PTMs

Methylation
Ubiquitination
Phosphorylation
Reduction

Acetylation
Sumoylation
Demethylation
Dephosphorylation

Research Areas

Cell Cycle and Replication
Epigenetics

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Kmt5a

References

PMID: 23468428 by Serrano L., et al. The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation.