N-lysine methyltransferase KMT5A (Kmt5a)

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Especially monomethylates'Lys-20' of histone H4 (H4K20me1).

H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.