Ragulator complex protein LAMTOR1 (LAMTOR1)

Included in the Ragulator complex it's involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor triggering the little GTPases Rag.

Activated Ragulator and Rag GTPases function as a scaffold recruitment mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes.