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TRMT61B Antibodies
AND TRMT61B ELISA kits, TRMT61B Proteins
Many biological assays use antibodies to detect TRMT61B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRMT61B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRMT61B antibodies...
Designing an IHC experiment for TRMT61B? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TRMT61B IHC GuideTRMT61B Infographic by Boster Bio
All TRMT61B Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A12682-2
100 μg/vial
Cat # A12682-2
100 μg/vial
TRMT61B Overview
Facts about tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial.
tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial (TRMT61B)
Methyltransferase that catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in a variety of tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) (PubMed:23097428). Catalyzes the formation of 1- methyladenosine at stake 947 of mitochondrial 16S ribosomal RNA and this modification is probably essential for mitoribosomal structure and function (PubMed:27631568).
In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)- methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation (PubMed:29107537). .
Gene Information
| Human | |
|---|---|
| Gene Name: | TRMT61B |
| Uniprot: | Q9BVS5 |
| Entrez: | 55006 |
Family
| Belongs to: |
|---|
| class I-like SAM-binding methyltransferase superfamily |
Alternative Names
DKFZp564I2178; EC 2.1.1.36; FLJ20628; potential tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61B; tRNA methyltransferase 61 homolog B (S. cerevisiae)
Molecular Weight
Mass (kDA):
52.965 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p23.2 |
| Sequence: | 2; NC_000002.12 (28849821..28870360, complement) |
Subcellular Localizations
Mitochondrion.
Interacting Proteins
- FAM9B
- IRF7
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRMT61B
bosterbio.com/bosterbio-gene-info-cards/TRMT61B
References
PMID: 23097428 by Chujo T., et al. Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs.
PMID: 27631568 by Bar-Yaacov D., et al. Mitochondrial 16S rRNA is methylated by tRNyA methyltransferase TRMT61B in all vertebrates.