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- Table of Contents
Myelin basic protein Antibodies
AND MBP ELISA kits, Myelin basic protein Proteins
Many biological assays use antibodies to detect Myelin basic protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Myelin basic protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Myelin basic protein antibodies...
Designing a Western blot for Myelin basic protein? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MBP Western Blot GuideMBP Infographic by Boster Bio
All MBP Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Pig, Rat
IF, IHC, WB
$370
Cat # PA1050
100 μg/vial
Cat # PA1050
100 μg/vial
Anti-ENO1 Antibody Picoband®
1 Citations
Human, Monkey, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # A01250-1
100 μg/vial
Cat # A01250-1
100 μg/vial
Mouse
ELISA
$500
Cat # EZ0806
For 5 plates, 96 wells each
Cat # EZ0806
For 5 plates, 96 wells each
Human, Mouse, Pig, Rat
IHC, WB
$370
Cat # M00211
100 μl
Cat # M00211
100 μl
Human, Mouse, Rat
IP, IF, ICC, WB
$370
Cat # M01250
100 μl
Cat # M01250
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A01003
100 μg/vial
Cat # A01003
100 μg/vial
Human
$628
Cat # LS004155
20 µg, 100 µg
Cat # LS004155
20 µg, 100 µg
Enzyme Activity, SDS-PAGE
$235
Cat # PROTP17182
Starting from 10ug
Cat # PROTP17182
Starting from 10ug
Enzyme Activity, SDS-PAGE
$243
Cat # PROTP06733
Starting from 20ug
Cat # PROTP06733
Starting from 20ug
MBP Overview
Facts about Myelin basic protein.
Myelin basic protein (MBP)
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization.
The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, possibly as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells.
Gene Information
| Human | |
|---|---|
| Gene Name: | MBP |
| Uniprot: | P02686 |
| Entrez: | 4155 |
Family
| Belongs to: |
|---|
| myelin basic protein family |
Alternative Names
Hmbpr; MBP; MGC99675; mld; Myelin A1 protein; myelin basic protein; Myelin membrane encephalitogenic protein; shi
Molecular Weight
Mass (kDA):
33.117 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q23 |
| Sequence: | 18; NC_000018.10 (76978833..77133708, complement) |
Tissue Specificity
MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.
Subcellular Localizations
Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic side of myelin.; [Isoform 3]: Nucleus. Targeted to nucleus in oligodendrocytes.
Diseases
- Experimental Autoimmune Encephalomyelitis
- Multiple Sclerosis
- Sclerosis
- Encephalomyelitis
- Autoimmune Reaction
- Nervousness
- Autoimmune Diseases
- Demyelinating Diseases
- Demyelination
- Hypertensive Disease
- Inflammation
- Autoimmunity
- Neoplasms
Interacting Proteins
- ADRB2
- CCR1
- CTDSP1
- Plk4
- PTAFR
Pathways
- Myelination
- Pathogenesis
- Immune Response
- Secretion
- Localization
- Transport
- Cell Proliferation
- Excretion
- Cell Death
- Oligodendrocyte Differentiation
- Hypersensitivity
- Translation
- Sensitization
PTMs
- Phosphorylation
- Cleavage
- Methylation
- Dephosphorylation
- Citrullination
- Biotinylation
- Glycosylation
- Oxidation
- Nitration
- Reduction
Research Areas
- Neuroscience
- Neurotransmission
- Oligodendrocyte Cell Markers
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MBP
bosterbio.com/bosterbio-gene-info-cards/MBP
References
PMID: 4108501 by Carnegie P.R.; Amino acid sequence of the encephalitogenic basic protein from human myelin.
PMID: 2427738 by Roth H.J., et al. Isolation and characterization of a cDNA coding for a novel human 17.3K myelin basic protein (MBP) variant.
19 Publications of Boster Myelin basic protein Antibodies & ELISA Kits
- PubMed ID: 10.2147/OTT.S222426, Roles Of EAAT1, DHFR, And Fetuin-A In The Pathogenesis, Progression And Prognosi...
- PubMed ID: 10.1016/j.celrep.2015.01.037, Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Ind...
- PubMed ID: 10.1016/j.brainresbull.2020.10.015, [Met5]-enkephalin preserves diffusion metrics in EAE mice
- PubMed ID: 31217864, Liu Y,Li L,Qiu M,Tan L,Zhang M,Li J,Zhu H,Jiang S,Su X,Li A.Renal and cerebral R...
- PubMed ID: 32515838, Meng FW,Jing XN,Song GH,Jie LL,Shen FF.Prox1 induces new lymphatic vessel format...
- PubMed ID: 29922213, Nexilin Regulates Oligodendrocyte Progenitor Cell Migration and Remyelination an...
- PubMed ID: 27580304, Cyclin-dependent kinase inhibitor flavopiridol promotes remyelination in a cupri...
- PubMed ID: 26572749, Effects of nerve growth factor and basic fibroblast growth factor dual gene modi...
- PubMed ID: 29623935, Zhou XB, Liu N, Wang D, Zou DX, Wei CW, Zhou JL. Neural Regen Res. 2018 Mar;13(3...
- PubMed ID: 25780400, Zhang M, Chai Y, Liu T, Xu N, Yang C. Exp Ther Med. 2015 Apr;9(4):1141-1148. Epu...
- PubMed ID: 24452272, Gao S, Zheng Y, Cai Q, Yao W, Wang J, Zhang P, Wang X. J Mater Sci Mater Med. 20...
- PubMed ID: 18365011, Wang B, Xiao Z, Chen B, Han J, Gao Y, Zhang J, Zhao W, Wang X, Dai J. Plos One. ...
- PubMed ID: 25777531, Jin Sj, Liu Y, Deng Sh, Liao Lh, Lin Tl, Ning Q, Luo Xp. Int J Mol Med. 2015 May...
- PubMed ID: 23619428, Wei J, Zheng M, Liang P, Wei Y, Yin X, Tang Y, Xue Y. Neurobiol Dis. 2013 Aug;56...
- PubMed ID: 25663200, Chen X,, Chen X, Huang X, Qin C, Fang Y, Liu Y, Zhang G, Pan D, Wang W, Xie M. M...
- PubMed ID: 24064494, Han Sm, Wan H, Kudo G, Foltz Wd, Vines Dc, Green De, Zoerle T, Tariq A, Brathwai...
- PubMed ID: 25834438, Yang P, Gao Z, Zhang H, Fang Z, Wu C, Xu H, Huang Qj. Neuropsychiatr Dis Treat. ...
- PubMed ID: 23164425, Wang X, Tu Q, Zhao B, An Y, Wang Jc, Liu W, Yuan Ms, Ahmed Sm, Xu J, Liu R, Zhan...
- PubMed ID: 21618540, Ping Yf, Yao Xh, Jiang Jy, Zhao Lt, Yu Sc, Jiang T, Lin Mc, Chen Jh, Wang B, Zha...
*More publications can be found for each product on its corresponding product page