Myelin basic protein Antibodies

Myelin basic protein (MBP)

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization.

The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, possibly as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells.

Gene Information

Human
Gene Name:	MBP
Uniprot:	P02686
Entrez:	4155

Family

Belongs to:
myelin basic protein family

Alternative Names

Hmbpr; MBP; MGC99675; mld; Myelin A1 protein; myelin basic protein; Myelin membrane encephalitogenic protein; shi

Molecular Weight

Mass (kDA):
33.117 kDA

Genomic Context

Human
Location:	18q23
Sequence:	18; NC_000018.10 (76978833..77133708, complement)

Tissue Specificity

MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.

Subcellular Localizations

Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic side of myelin.; [Isoform 3]: Nucleus. Targeted to nucleus in oligodendrocytes.

Diseases

• Experimental Autoimmune Encephalomyelitis
• Multiple Sclerosis
• Sclerosis
• Encephalomyelitis
• Autoimmune Reaction
• Nervousness
• Autoimmune Diseases
• Demyelinating Diseases
• Demyelination
• Hypertensive Disease
• Inflammation
• Autoimmunity
• Neoplasms

• Cns Disorder
• Tissue Adhesions
• Malignant Neoplasms
• Hypotension Adverse Event
• Cerebrovascular Accident
• Brain Injuries
• Asthma

Interacting Proteins

• ADRB2
• CCR1
• CTDSP1
• Plk4
• PTAFR

Pathways

• Myelination
• Pathogenesis
• Immune Response
• Secretion
• Localization
• Transport
• Cell Proliferation
• Excretion
• Cell Death
• Oligodendrocyte Differentiation
• Hypersensitivity
• Translation
• Sensitization

• Cell Activation
• Proteolysis
• Cytokine Production
• Cell Cycle
• Inflammatory Response
• Regeneration
• T Cell Activation

PTMs

• Phosphorylation
• Cleavage
• Methylation
• Dephosphorylation
• Citrullination
• Biotinylation
• Glycosylation
• Oxidation
• Nitration
• Reduction

• Deamidation
• Acetylation
• Acylation
• Ribosylation
• Deglycosylation
• Ubiquitination
• Myristoylation
• Carboxylation
• Amidation
• Iodination

Research Areas

• Neuroscience
• Neurotransmission
• Oligodendrocyte Cell Markers
• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MBP

Best Uses Of The MBP Marker From Boster Bio's Super Vision Detection Kits

In this article, you will learn more about how to use the primary-secondary-ABC system of Boster Bio's Super Vision Detection kits to identify proteins with high specificity and low background. This product is a great tool that are accessible to all scientists. Let's get started! Let's first look at the MBP Marker. It is a fluorescent marker that has high resolution that lets researchers identify proteins that have high specificity and low background.

Boster Bio's primary-secondary-ABC system allows researchers to locate proteins with low background and high specificity

A recent study published in Science Advances describes how a new method of detecting proteins from Boster Bio's primary-secondary ABC system can help researchers discover more proteins with high specificity and low background. The primary-secondary-ABC system uses a two-stage PAGE process to separate proteins from healthy mixed sera and transfers them to a PVDF or NC membrane. In the second step, membranes are tested for their re-probed ability by running these samples through the primary-secondary-ABC system again.

The primary-secondary-ABC system at Boster Bio is a powerful tool for protein identification. Due to its high specificity and low background, researchers can find even the most difficult or difficult-to-detect proteins. Boster Bio has also assisted researchers in developing their understanding of the immune system and developing treatments for inflammatory bowel diseases. Researchers studying autoimmune diseases are searching for new ways to use immune system to treat patients and target tumors.

According to the study, allergic reactions are caused by a subset of immune cells. This discovery could help researchers discover the causes of allergies and how to block the triggering of allergies. Th2A cells are involved in the development of allergies. Therefore, finding an inhibitory molecule could result in a treatment for all kinds of allergies. In the meantime, the new technology could offer a revolutionary way to fight allergies and autoimmune diseases.

The results of the primary-secondary-ABC system are consistent with the first staining. Additionally, researchers can use the Boster Bio primary-secondary-ABC system to locate proteins with low background and high specificity. Researchers can isolate proteins with low background and a high level of specificity without having conduct multiple tests.

Among the primary-secondary-ABC system, Boster Bio's P-S-S-ABC method enables researchers to find proteins with low background and high specificity. With low background and high specificity, the primary-secondary-ABC method enables researchers to locate proteins with low background and high sensitivity.

As part of the initial research, Dr. McCormick and her team discovered a novel pathway in the immune system that protects host cells from viruses such as COVID-19. The engineered regulatory T cells were able block "dangerous effector T" cells. The next step is to treat these cells in type 1 diabetes patients and transform them into regulatory T cells. This could result in a long-term cure.

Among the most promising applications of the Boster-ABC-system is identification of autoimmune disorders. Type 1 diabetes and Rheumatoid Arthritis are known targets for antigens. Lupus and other autoimmune disorders can be difficult and complex to identify. In such instances, identifying the cause and evaluating the effectiveness of a particular therapy may be required to treat the disease.

Super Vision Detection kits enable researchers to discover proteins with low background and high sensitivity.

Boster Bio's Super-Vision Detection Kits let researchers find proteins with high specificity and low background using its revolutionary ELISA technology. These high-sensitivity kits are perfect for research in protein and Boster Bio's technical support and customized services make them the perfect choice for any research requirements. PicoKine(tm) is the company's proprietary ELISA platform, provides high-sensitivity ELISA kit that has unparalleled sensitivity and precision.

The MBP Marker has many benefits

The MBP marker is one of the most recent methods for assessing myelin elasticity. It is essential to the formation of the CNS's principal dense line. It is also an elastic protein that works well with multiple binding partners. Utilizing the MBP marker can aid researchers identify these interactions and their effect on myelin elasticity. There are many benefits to MBP markers however these are just some.

MBP is an important molecule that has been associated with many neurological disorders. Although there is no one antigen for MBP. Certain studies have suggested that antibodies against MBP could play a role in MS. While some research has identified genetic predispositions to MS to MBP however, the majority of studies haven't established this link. Whatever the case, the advantages of MBP testing shouldn't be overlooked. This marker can aid medical professionals and researchers catch diseases early and prevent disability.