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- Table of Contents
Mitofusin-2 Antibodies
AND MFN2 ELISA kits, Mitofusin-2 Proteins
Many biological assays use antibodies to detect Mitofusin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Mitofusin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Mitofusin-2 antibodies...
Designing a Western blot for Mitofusin-2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MFN2 Western Blot GuideDesigning an IHC experiment for Mitofusin-2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the MFN2 IHC GuideMFN2 Infographic by Boster Bio
All MFN2 Products
Product
Figures
Specificity
Applications
Price
Anti-Mitofusin 2 MFN2 Rabbit Monoclonal Antibody
10 Citations
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00461
100 μl
Cat # M00461
100 μl
Anti-Mitofusin 2/MFN2 Antibody Picoband®
3 Citations
Human, Mouse, Rat
WB
$370
Cat # PB9265
100 μg/vial
Cat # PB9265
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00461-1
20μL, 40μL, 100μL, 200μL
Cat # M00461-1
20μL, 40μL, 100μL, 200μL
MFN2 Overview
Facts about Mitofusin-2.
Mitofusin-2 (MFN2)
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:28114303). Mitochondria are exceptionally dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303).
Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and might involve a significant rearrangement of the coiled coil domains (Probable).
Gene Information
| Human | |
|---|---|
| Gene Name: | MFN2 |
| Uniprot: | O95140 |
| Entrez: | 9927 |
Family
| Belongs to: |
|---|
| TRAFAC class dynamin-like GTPase superfamily |
Alternative Names
CMT2A; CMT2A2; CPRP1; CPRP1mitochondrial assembly regulatory factor; EC 3.6.5; EC 3.6.5.-; HSG; KIAA0214hyperplasia suppressor; MARF; MFN2; Mitofusin 2; mitofusin-2; Transmembrane GTPase MFN2
Molecular Weight
Mass (kDA):
86.402 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.22 |
| Sequence: | 1; NC_000001.11 (11980181..12013515) |
Tissue Specificity
Ubiquitous; expressed at low level. Highly expressed in heart and kidney.
Subcellular Localizations
Mitochondrion outer membrane; Multi-pass membrane protein. Colocalizes with BAX during apoptosis.
Diseases
- Charcot-marie-tooth Disease
- Atrophy
- Optic Atrophy
- Peripheral Neuropathy
- Neurodegenerative Disorders
- Optic Atrophy, Autosomal Dominant
- Diabetes Mellitus
- Inherited Neuropathy
- Mitochondrial Diseases
- Parkinson Disease
- Hereditary Motor And Sensory Neuropathies
- Obesity
Interacting Proteins
- LRRK2
- MFN1
- PRKN
- SAMM50
Pathways
- Mitochondrial Fusion
- Mitochondrial Fission
- Pathogenesis
- Cell Death
- Membrane Fusion
- Cell Proliferation
- Transport
- Cell Cycle
- Autophagy
- Oxidative Phosphorylation
- Localization
- Aging
- Rna Interference
PTMs
- Phosphorylation
- Ubiquitination
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MFN2
bosterbio.com/bosterbio-gene-info-cards/MFN2
References
PMID: 12598526 by Bach D., et al. Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity.
PMID: 15322553 by Chen K.-H., et al. Dysregulation of HSG triggers vascular proliferative disorders.
2 Publications of Boster Mitofusin-2 Antibodies & ELISA Kits
- PubMed ID: 32884840, Jiao Z,Wu Y,Qu S.Fenpropathrin induces degeneration of dopaminergic neurons via ...
- PubMed ID: 24928681, Montaigne D, Marechal X, Coisne A, Debry N, Modine T, Fayad G, Potelle C, El Ari...
*More publications can be found for each product on its corresponding product page