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- Table of Contents
NDEL1 Antibodies
AND NDEL1 ELISA kits, NDEL1 Proteins
Many biological assays use antibodies to detect NDEL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NDEL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NDEL1 antibodies...
Designing a Western blot for NDEL1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NDEL1 Western Blot GuideDesigning an IHC experiment for NDEL1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the NDEL1 IHC GuideNDEL1 Infographic by Boster Bio
All NDEL1 Products
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NDEL1 Overview
Facts about Nuclear distribution protein nudE-like 1.
Nuclear distribution protein nudE-like 1 (NDEL1)
Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome.
Also positively regulates the activity of this minus-end directed microtubule motor protein dynein. May improve dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends.
Gene Information
| Human | |
|---|---|
| Gene Name: | NDEL1 |
| Uniprot: | Q9GZM8 |
| Entrez: | 81565 |
Family
| Belongs to: |
|---|
| nudE family |
Alternative Names
DKFZp451M0318; EOPA; MITAP1mitosin-associated protein MITAP1; Mitosin-associated protein 1; nuclear distribution protein nudE-like 1; nudE nuclear distribution gene E homolog (A. nidulans)-like 1; nudE nuclear distribution gene E homolog like 1 (A. nidulans); nudE nuclear distribution gene E homolog like 1; NUDELendooligopeptidase A; NUDE-like protein; Protein Nudel
Molecular Weight
Mass (kDA):
38.375 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.1 |
| Sequence: | 17; NC_000017.11 (8435884..8472744) |
Tissue Specificity
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
Subcellular Localizations
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the kinetochore in a CENPF-dependent manner.
Diseases
- Schizophrenia
- Lissencephaly
- Mental Disorders
- Nervousness
- Mood Disorders
- Classical Lissencephaly
- Neurodegenerative Disorders
- Bipolar Disorder
- Psychotic Disorders
- Brain Diseases
- Nervous System Disorder
- Tissue Adhesions
Interacting Proteins
- AIMP2
- BMI1
- BORCS6
- BRK1
- CENPF
- CWF19L2
- DISC1
- DTNB
- GOLGA2
- KIFC3
Pathways
- Transport
- Localization
- Cell Division
- Brain Development
- Mitosis
- Neurogenesis
- Rna Interference
- Spindle Assembly
- Cell Death
- Cell Proliferation
- Nuclear Migration
- Pathogenesis
- Cell Cycle
PTMs
- Phosphorylation
- Cleavage
- Nitrosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NDEL1
bosterbio.com/bosterbio-gene-info-cards/NDEL1
References
PMID: 11163260 by Niethammer M., et al. NUDEL is a novel cdk5 substrate that associates with LIS1 and cytoplasmic dynein.
PMID: 12556484 by Yan X., et al. Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle.