Noelin-2 Antibodies

AND OLFM2 ELISA kits, Noelin-2 Proteins

Many biological assays use antibodies to detect Noelin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Noelin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Noelin-2 antibodies...

We validate the specificity of these antibodies to Noelin-2 by testing them on tissues known to express OLFM2 positively and negatively. Browse below to find the OLFM2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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OLFM2 Infographic by Boster Bio

All OLFM2 Products

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Specificity

Applications

Price

OLFM2 (NM_058164) Human Over-expression Lysate

Human

$628
Cat # LS093145
20 µg, 100 µg

Human Olfactomedin-2/Noelin-2 ELISA Kit PicoKine®

Human

ELISA

$750
Cat # EK2272
96 wells/kit, with removable strips.

OLFM2 Overview

Facts about Noelin-2.

OLFM2 3D structure. Source: alphafold

Noelin-2 (OLFM2)

Involved in transforming growth factor beta (TGF-beta)- induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 into the nucleus where it binds to SRF, inducing its dissociation in the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399).

Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF.

Gene Information

Human
Gene Name:	OLFM2
Uniprot:	O95897
Entrez:	93145

Family

Belongs to:

No superfamily

Alternative Names

neuronal olfactomedin related ER localized protein 2; NOE2; NOE2noelin 2; NOELIN2; Noelin-2; NOELIN2_V1; olfactomedin 2; Olfactomedin2; Olfactomedin-2; OlfC; OLFM2; OM2

Molecular Weight

Mass (kDA):
51.386 kDA

Genomic Context


Human

Location:	19p13.2
Sequence:	19; NC_000019.10 (9853718..9936515, complement)

Tissue Specificity

Expressed in aortic smooth muscle (at protein level) (PubMed:25298399). In the fetus, expressed in the brain and ocular tissues including lens vesicle and optic cup (PubMed:27844144).

Subcellular Localizations

Secreted. Cell junction, synapse. Membrane. Nucleus. Cytoplasm. Nuclear localization is induced by TGF-beta.

Diseases

Glaucoma
Cell Transformation, Neoplastic
Premature Menopause
Nervousness
Ocular Hypertension
Intraocular Pressure Disorder
Communicable Diseases

Glaucoma, Open-angle

Pathways

Transport
Cell Cycle
Ion Transport
Immune Response
Menopause
Menarche
Eye Development
Localization

Protein Ubiquitination
Secretion
Oncogenesis

PTMs

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OLFM2

References

PMID: 15123989 by Mukhopadhyay A., et al. Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders.

PMID: 21228389 by Sultana A., et al. Olfactomedin 2: expression in the eye and interaction with other olfactomedin domain-containing proteins.