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- Table of Contents
Facts about Pancreas/duodenum homeobox protein 1.
Included in a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'.
Human | |
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Gene Name: | PDX1 |
Uniprot: | P52945 |
Entrez: | 3651 |
Belongs to: |
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Antp homeobox family |
Glucose-sensitive factor; IDX1; IDX-1GSF; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; Insulin upstream factor 1; IPF1; IPF1pancreas/duodenum homeobox protein 1; Islet/duodenum homeobox-1; MODY4IUF1; pancreatic and duodenal homeobox 1; pancreatic-duodenal homeobox factor 1; PDX-1; PDX-1IPF-1; somatostatin transcription factor 1; Somatostatin-transactivating factor 1; STF-1IUF-1
Mass (kDA):
30.771 kDA
Human | |
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Location: | 13q12.2 |
Sequence: | 13; NC_000013.11 (27919982..27926313) |
Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).
Nucleus. Cytoplasm, cytosol.
You've probably heard about the PDX1 gene and its benefits But did you know that there are several other versions of this enzyme that are available? Here are the best uses of PDX1, PDX2, and PDX3 markers. These enzymes play an essential role in the creation of a healthy body and an effective immune system. This article will provide more information.
The PDX1 molecular marker is one of the most important boster bio. It was discovered recently. PDX1 is an important transcription factor that plays a role in regulating the fate of cells. Progenitors of Pdx1+ cells exhibit distinct patterns of expression at various developmental stages including E9.5 to E11.5. This indicates that the pattern of expression of Pdx1 is determined by the timing program as well as the inductive milieu.
The adult pancreas is composed of various types of cells including the exocrine Acini, which secrete digestive enzymes, and the islets of Langerhans that are home to cells that regulate the body's hormones. All of these types of cells are derived from two endodermal areas that express Pdx1. It is interesting to note that the expression patterns of Pdx1 and Nkx6.1 are not synchronized.
If you decide to test for the PDX2 Marker in Boster, you'll have a wide range of options. You can also submit samples of a specific species or application, and Boster will automatically give you credit for the product. The Boster Bio optimization guides and tips can help you optimize your research. Once you have chosen your flow procedure it's time to create your Boster Bio experiment.
PDX3 is a vital component in many cancer research studies. But what is the most effective concentration? What are the elements that affect the concentration of PDX3 in cell-culture studies? Learn how to utilize PDX3 or other primary antibodies to determine the best concentration for your research. Next, select the best flow procedure for your cell-culture experiments. Once you've completed your flow process, you will be presented with a variety of choices.
Scientists are discovering a variety of applications for the PDX1 marker in their experiments. The protein has been proven to attach to DNA sequences within the promoter region of the MafB gene. Scientists have been able to determine binding locations for Pdx1 by using the test of gel mobility shift on bTC3 nuclear extract. Additionally, chromatin immunoprecipitation experiments have revealed that Pdx1 binds to MafB endogenous in Min6 cells.
The PDX1 master regulator acts as a key regulator for b-cell fate. It regulates genes related to the identity of a cell and activates genes that are critical for b-cell development. It has been demonstrated that it is responsible for the development and maintenance of diabetes type 2 by altering maturation of b-cells. These findings suggest that the Pdx1 gene could be a major player in a range of diseases, from diabetes to Alzheimer's disease.
You might be curious about the significance of the Pdx1 gene when you hear it mentioned in connection with blood cells. This protein is a master regulator of b-cell fate, activating genes that are required for b-cell identity and inhibiting genes that are associated with a-cell identity. These findings are discussed in the context of how the loss of b cell identity may contribute to the development of type 2 diabetes.
It was discovered that PDX1 is responsible for the proliferation, differentiation, and function of islet b-cells. In humans, the decreased expression of this gene is connected to decreased b-cell mass. Therefore, promoting PDX1 expression is a promising method for preserving b-cell mass. Recent studies have shown that tectorigenin is a potential promoter of the PDX1 gene in human cells.
The PDX1 gene encodes a protein which plays a major function in the development and production of insulin, a hormone which is produced in the pancreas. In in vivo, this protein plays a major part in the defining of various endocrine lineages , as well as the maturation of beta cells. This is why it is crucial in the development of insulin-producing cells as well as other diabetic tissues.
The PDX1 marker (a sensitive DNA-binding protein, regulates b cell development, differentiation and functions in the pancreas. Low levels of PDX1 are linked to less b-cell mass in patients with diabetes. Researchers can boost PDX1 expression to help preserve the function and mass of b-cells. To accomplish this one gene, tectorigenin, was identified as a possible promoter of the PDX1 gene.
The fate of B cells is controlled by the PDX1 gene. It activates genes that are linked to b cell identity and suppresses genes that are associated with a-cell identification. B-cells depleted by Pdx1 develop the characteristics of a-cells and transform into a-cells. These findings were made in the context of type 2 diabetes and the role of the Pdx1 gene.
PDX1 is one of the genes that is located on the chromosome and is responsible for the expression c-Myc. This is a significant regulator of cell growth. It is often found in tissues of various species. This gene isn't present in a large number of human tissues. The best uses of the PDX1 gene aren't yet discovered. Here are some potential uses for PDX1.
The PDX1 gene is an essential master regulator of b-cell fate. It regulates the expression of genes that are associated with b cell identity and suppresses the genes associated with a-cell identities. These findings are discussed in relation to the loss of b-cell identity that occurs in type 2 diabetes. In addition, a mouse with a deficient PDX1 model is the most helpful in studying the functions of Pdx1.
The PDX1 gene is a transcription element called a homeobox that regulates islet B cells' activity, acts as a regulator of their activities. Patients with diabetes may experience reduced levels of PDX1 which can cause beta cells of the islet to loss. However, increasing PDX1 expression in diabetes-prone islets can help preserve their mass. Scientists have identified a gene promoter known as Tectorigenin, which could aid in promoting PDX1 expression.
Both PDX10 and Boster Bio have been shown to decrease NLRP3 expression in vitro, along with CASP-1 and IL-1b. These compounds are believed to restrain NLRP3 signaling, thus reducing inflammatory responses and changing the balance of Treg and Th27 cells. But, a lot of questions remain about the effectiveness of these compounds in reducing inflammation.
Although there are several products available but not all are as effective as others. PDX10 for instance, has the potential to inhibit the NLRP3 receptor and regulate Treg/Th27 cell balance. However, more studies are required to confirm these findings on humans. It is therefore crucial to ensure that your experiments are optimized before you begin your experiments. PDX10 and Boster Bio may be a good option for your lab.
PMID: 7590740 by Stoffel M., et al. Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1.
PMID: 8635654 by Inoue H., et al. Isolation, characterization, and chromosomal mapping of the human insulin promoter factor 1 (IPF-1) gene.