Proto-oncogene tyrosine-protein kinase receptor Ret (RET)

Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1.

Regulates both cell death/survival balance and positional information. Required for the molecular mechanics orchestration during intestine organogenesis; involved in the growth of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major part of the gut- associated lymphoid tissue.