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- Table of Contents
Facts about Proto-oncogene tyrosine-protein kinase receptor Ret.
Regulates both cell death/survival balance and positional information. Required for the molecular mechanics orchestration during intestine organogenesis; involved in the growth of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major part of the gut- associated lymphoid tissue.
Human | |
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Gene Name: | RET |
Uniprot: | P07949 |
Entrez: | 5979 |
Belongs to: |
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protein kinase superfamily |
CDHF12MTC1; CDHR16; EC 2.7.10; Hirschsprung disease 1; Hirschsprung disease); MEN2A; MEN2B; multiple endocrine neoplasia and medullary thyroid carcinoma 1; ret proto-oncogene; RET transforming sequence; Ret
Mass (kDA):
124.319 kDA
Human | |
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Location: | 10q11.21 |
Sequence: | 10; NC_000010.11 (43077027..43130351) |
Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Predominantly located on the plasma membrane. In the presence of SORL1 and GFRA1, directed to endosomes.
This guide will help you maximize your experiments using the RET Marker. These tips and tricks will help you optimize your research to get the most effective results. Every researcher will face challenges during their research as with any other experiment. There are a variety of ways to eliminate the most common sources of error and improve the results of your experiments. A good guide can help you to identify and eliminate the issues.
RET is a protein that covers the cell membrane with one end within the cell and the other outside. It responds to signals from the outside and interacts with external influences. The protein binds itself to growth factors which trigger complex chemical reactions inside the cell. It is then instructed to undergo specific changes or perform specialized functions. The protein plays an essential part in the development of the kidneys, spermatogenesis and the autonomic nervous systems.
The tumor microenvironment expresses RET, which is associated with tumor growth, metastasis-free survival , and lower overall survival. GFL is a molecule which is associated with cancer-fighting immune cell cells, is also found to be higher in RET-expressing tumors. Further studies are likely to show that RET expression is an intricate web of paracrine and autocrine signals. These signals facilitate the remodeling of the tumor environment and increase the oncogenic potential of tumors that express RET.
Over 30 types of tumors are affected by RET-mutations. Mutations in the RET receptor are classified into two categories based on their mutational mechanism and are associated with distinct cancer types. These classes of tumors may be especially beneficial in guiding the management of disease. The RET mutational mechanism is the most significant factor in controlling the activity of the receptor and RET-targeting therapy can be beneficial to a wide range of human cancers.
RET mutations offer important prognostic information for thyroid nodules that have undetermined cytology. Although RET rearrangements don't require PTC formation, they may be associated with more malignant phenotypes. This means that RET rearrangements could be an underlying risk factor for thyroid nodules with unclear cytology. In addition to helping to predict cancer risk, RET expression can be helpful in the diagnosis of thyroid nodules that are not thyroid-related.
PMID: 2660074 by Takahashi M.; Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence.
PMID: 3078962 by Takahashi M., et al. Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains.