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- Table of Contents
REV3L Antibodies
AND REV3L ELISA kits, REV3L Proteins
Many biological assays use antibodies to detect REV3L, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with REV3L in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop REV3L antibodies...
Designing an IHC experiment for REV3L? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the REV3L IHC GuideREV3L Infographic by Boster Bio
All REV3L Products
Product
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Specificity
Applications
Price
REV3L Overview
Facts about DNA polymerase zeta catalytic subunit.
DNA polymerase zeta catalytic subunit (REV3L)
Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.
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Gene Information
| Human | |
|---|---|
| Gene Name: | REV3L |
| Uniprot: | O60673 |
| Entrez: | 5980 |
Family
| Belongs to: |
|---|
| DNA polymerase type-B family |
Alternative Names
EC 2.7.7; EC 2.7.7.7; hREV3; Protein reversionless 3-like; REV3 (yeast homolog)-like, catalytic subunit of DNA polymerase zeta; REV3-like; REV3-like, catalytic subunit of DNA polymerase zeta (yeast); yeast, homolog-like (polymerase, DNA, zeta)
Molecular Weight
Mass (kDA):
352.776 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q21 |
| Sequence: | 6; NC_000006.12 (111299031..111483715, complement) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Genomic Instability
- Carcinoma
- Fanconi Anemia
- Colonic Neoplasms
- Glioma
- Malignant Tumor Of Colon
- Cytogenetic Abnormality
- Anemia
- Malignant Neoplasm Of Breast
- Lymphoma
Interacting Proteins
- MAD2L2
Pathways
- Translesion Synthesis
- Cell Cycle
- Dna Replication
- Dna Repair
- Mismatch Repair
- S Phase
- Cell Growth
- G2 Phase
- Localization
- Senescence
- Error-prone Translesion Synthesis
- Double-strand Break Repair
- Cell Cycle Arrest
PTMs
- Phosphorylation
Research Areas
- DNA Polymerases
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/REV3L
bosterbio.com/bosterbio-gene-info-cards/REV3L
References
PMID: 9618506 by Gibbs P.E.M., et al. A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta.
PMID: 10102035 by Lin W., et al. A full-length cDNA of hREV3 is predicted to encode DNA polymerase zeta for damage-induced mutagenesis in humans.