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- Table of Contents
Facts about Secretoglobin family 3A member 1.
.
Mouse | |
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Gene Name: | Scgb3a1 |
Uniprot: | Q920D7 |
Entrez: | 68662 |
Belongs to: |
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secretoglobin family |
cytokine high in normal-1; Cytokine HIN-1; High in normal 1; HIN1; HIN-1; HIN1Pneumo secretory protein 2; LU105; PNSP2; PnSP-2; PnSP-2Uteroglobin-related protein 2; SCGB3A1; secretoglobin family 3A member 1; secretoglobin, family 3A, member 1; UGRP2; UGRP2MGC87867
Mass (kDA):
10.591 kDA
Mouse | |
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Location: | 11 B1.2|11 29.75 cM |
Sequence: | 11; |
Highly expressed in lung, where it localizes to epithelial cells lining the trachea and bronchi (PubMed:12406855, PubMed:12175512). Expression in lung is mainly restricted to bronchi, submucosal glands of the trachea, and tracheal epithelium, with little expression in terminal bronchioles (PubMed:12406855). Expressed in uterus where it localizes to epithelial cells of the uterine glands (PubMed:12175512). Also detected in heart, stomach and small intestine (PubMed:12175512).
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The SCGB3A1 transfection agent is designed to promote and express gene expression in human cells. The unique structure of the reagent makes it compatible with aqueous buffers. Organic solvents are not required for complex preparations. Trans-Booster has been designed to work with attachment-dependent cell lines and suspension-growing cell lines. It results in non-integrating particles ranging in size from 100-200nm.
The SCGB3A1 is a transfection reagent that uses non-viral delivery system. The unique capabilities of this reagent include the use of novel chemistries or polymers. Mirus SCGB3A1 has a unique ability to deliver RNA, and other genetically modified genes, without any cytotoxicity. Unlike other reagents, SCGB3A1 is safe and effective for human cell culture, allowing researchers to test and refine their treatments.
The SCGB3A1 gene, also known as high-in-normal-1, encodes a 104-amino-acid protein. It is a member to the secretoglobin clan, which includes secretory molecules that regulate cellular functions. The secretoglobin3A1 gene is present in epithelial and basal cells. It plays a vital role in cell proliferation, differentiation, morphogenesis and cell division. Abnormal expression of this gene in human tumors can lead to malignant phenotype. A link between breast cancer and aberrant methylation has been established.
Researchers have identified four genes that express differently in the lung than other types. These genes encode members of the secretoglobin families 3A, INHBB and SCGB3A1 as well as INHBB-H. These four genes differ in expression in epithelial and lung ECs. This gene can be used to identify cancer cells and their characteristics.
These markers promote stem cell properties. The formation of spheres was increased by the SCGB3A1 protein and INHBBH in breast cancer cells. Other proteins such as OPG and LAMA1 had no effect. Recombinant SCGB3A1 and INHBB homodimers also increased the formation of spheres.
Survival in breast carcinoma is associated with the methylation level of the SCGB3A1 genetic. Researchers used logistic regression to assess the methylation of nine genes. SCGB3A1 methylation was correlated both with the expression of hormone receptors ER (and PR) and with the likelihood that breast cancer will occur. The genetic basis of the association between SCGB3A1 and breast cancer-associated mortality was not determined by the study.
PMID: 11481438 by Krop I.E., et al. HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells.
PMID: 11682631 by Niimi T., et al. UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor.