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- Table of Contents
SMURF1 Antibodies
AND SMURF1 ELISA kits, SMURF1 Proteins
Many biological assays use antibodies to detect SMURF1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMURF1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMURF1 antibodies...
Designing a Western blot for SMURF1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SMURF1 Western Blot GuideDesigning an IHC experiment for SMURF1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SMURF1 IHC GuideSMURF1 Infographic by Boster Bio
All SMURF1 Products
Product
Figures
Specificity
Applications
Price
Anti-SMURF1 Antibody Picoband®
2 Citations
Human, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9892
100 μg/vial
Cat # PB9892
100 μg/vial
SMURF1 Overview
Facts about E3 ubiquitin-protein ligase SMURF1.
E3 ubiquitin-protein ligase SMURF1 (SMURF1)
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway.
Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404).
Gene Information
| Human | |
|---|---|
| Gene Name: | SMURF1 |
| Uniprot: | Q9HCE7 |
| Entrez: | 57154 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
E3 ubiquitin ligase SMURF1; EC 6.3.2; EC 6.3.2.-; hSMURF1; KIAA1625; KIAA1625E3 ubiquitin-protein ligase SMURF1; SMAD specific E3 ubiquitin protein ligase 1; SMAD ubiquitination regulatory factor 1; Smad-specific E3 ubiquitin ligase 1; SMAD-specific E3 ubiquitin-protein ligase 1; SMURF1
Molecular Weight
Mass (kDA):
86.114 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q22.1 |
| Sequence: | 7; NC_000007.14 (99027435..99144118, complement) |
Tissue Specificity
Expressed in melanocytes (PubMed:23999003).
Subcellular Localizations
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Diseases
- Malignant Neoplasms
- Neoplasms
- Fibrosis
- Inflammation
- Malignant Neoplasm Of Pancreas
- Cell Invasion
- Neoplasm Metastasis
- Carcinoma
- Pancreatic Neoplasm
- Protrusion
- Tissue Adhesions
- Hypoxia
- Adenocarcinoma
Interacting Proteins
- CHEK1
- FBXL15
- ING2
- KLF2
- PLEKHO1
- PSME3
- RHOA
- RHOB
- SMAD1
- SMAD7
Pathways
- Osteoblast Differentiation
- Cell Migration
- Cell Proliferation
- Cell Growth
- Cell Differentiation
- Localization
- Rna Interference
- Pathogenesis
- Proteolysis
- Nuclear Export
- Cell Motility
- Bone Resorption
- Secretion
PTMs
- Ubiquitination
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMURF1
bosterbio.com/bosterbio-gene-info-cards/SMURF1
References
PMID: 10458166 by Zhu H., et al. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation.
PMID: 11163210 by Kavsak P., et al. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-beta receptor for degradation.