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Facts about Transcription factor SOX-2.
May function as a change in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity).
Human | |
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Gene Name: | SOX2 |
Uniprot: | P48431 |
Entrez: | 6657 |
Belongs to: |
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No superfamily |
ANOP3; MCOPS3; MGC2413; SOX2; SRY (sex determining region Y)-box 2; SRY-related HMG-box gene 2; transcription factor SOX2; transcription factor SOX-2
Mass (kDA):
34.31 kDA
Human | |
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Location: | 3q26.33 |
Sequence: | 3; NC_000003.12 (181711925..181714436) |
Nucleus.
The SOX2Marker is an excellent marker that can be used to study the gene expression patterns of certain cells and tissues. Its main uses are in the regulation of gene expression within the stomach and maintenance of neural stem cells. Boster scientists are able to submit their results and get product credits. This marker is available to all scientists around the world. Learn more about the advantages of this marker. This article also discusses its benefits.
Boster Bio's anti-SOX2 monoclonal antibodies have been tested in IF, IHC–P, and WB assays. It reacted with human SOX2 and was purified using a protein G column. The antibody was raised against synthetic peptides that contain 15 amino acids. These amino acids are near the human SOX2 amino terminus. For a specific length of immunogen, blocking peptides can be purchased at a price based on the length of the immunogen.
This primary antibody was validated across multiple platforms using known positive samples and negative samples. Its high affinity and specificity were demonstrated. The technical support provided by Sanbio, a BeNeLux distributor, backs this antibody. Boster's antibodies are based on research from immunogen design. They also come with a long list of references that validate their products. This allows customers to be confident in Boster’s quality antibodies.
The SOX2 protein is found in the human genome, where it has been shown to play a crucial role in the maintenance of neural and embryonic stem cells. This protein holds great promise for research into induced psoripotency. The synthetic peptides used to produce the antibody are 171-183 amino acids. These amino acids differ from their orthologs in the rat and mouse by one amino.
Boster Bio manufactures the Anti SOX2 Monoclonal. They are a well-respected antibody company. This company specializes on the production of picogram-sensitive ELISA kit kits. Their vast array of antibodies includes picogram-sensitive ELISA kit kits and IHC optimized polyclonal antibody. A large number of citations have been given to their products due to the company's dedication to quality and excellent customer service. Boster Bio products all come with the Boster Guarantee.
Increasing evidence suggests that SOX2 regulates gastric cell proliferation. Two gastric cell lines were inhibited by SOX2 overexpression. Overexpression SOX2 reduced levels of cyclinD1 and phosphorylated Rb proteins, while knockdown SOX2 increased levels of p27Kip1 Protein. SOX2-deficient cells had higher G1 phase.
Hypermethylated SOX2 is associated to shorter survival rates in gastric cancer. Low expression of p27Kip1 protein is inversely correlated with poor prognosis in gastric cancer. Similarly, methylation OFX2 is associated to decreased expression of cyclin D1, a key regulator in the immune system. In fact, SOX2-deficient patients have a poor prognosis.
The epithelial cells of both the gizzard & proventriculus contain the cSox2 protein. The caudal limit of SOX2 expression coincides with the rostral limit of CdxA, a gene of the caudal-related homeobox gene family. SOX2 is found in the stomach mucosa and the pyloric mucosa, but not in the intestine. The expression of SOX2 is also significantly lower in gastric carcinoma tissues, suggesting that it may be a marker to a nutrient-resistance condition.
The SOX2 mark regulates the expression and function of genes in the gastrointestinal track. It has many roles in tumorigenesis and pathway-dependent pluripotency. We are still not able to identify the underlying mechanisms of SOX2 expression. In mouse embryogenesis, the SOX2 gene family was found to be dynamically controlled. These results suggest that SOX2 plays a significant role in the development and progression of tumors in esophagus.
This study was done in two cell lines (MKN45 & TGBC11TKB). SOX2 caused a "cancer stem-cell" state in both cell types. This led to an increase in the aggressiveness of these tumors, and a poorer prognosis. This finding may help us better understand the mechanisms of sporadic cancer. It is also important for future research, particularly in clinical trials.
These tumors were found to have a lower overall survival rate that those that express SOX2. CDX2 expression strongly correlates with poor prognosis for patients with colorectal carcinoma. Researchers conclude that this gene is important in the development and progression of colorectal carcinoma.
The SOX2 gene is a key component of the gene regulatory system that regulates the differentiation of a variety stem cells, including ESCs as well as NSCs. It is not known if it acts as a transcriptional activator or repressor. It is not known how SOX2 regulates neural stem-cell maintenance. This could be due in part to the fact that SOX2 is often mutated, and not well expressed in regenerative medicine.
Although the role of SOX2 is not fully understood in neural stem-cell maintenance, it has been shown that it is involved in self-renewal and maintenance of NSC. SOX2 regulates Lin28 expression, which is an important marker of neuronal structure. In addition, SOX2-deficient adult NPCs display aberrant dendritic maturation and electrophysiology.
Interestingly, the SOX2 gene also has important roles in neuronal differentiation. It promotes a poised chromatin state in neurogenic genes, enabling appropriate activation of differentiation upon a neurogenic stimulus. The gene itself, which is bivalently expressed, has been implicated as a factor in many diseases, including schizophrenia. In this context the best uses of SOX2 gene for neural-stem-cell maintenance are those which improve the quality of lives of patients suffering from neurological disorders.
Sox2 is implicated in neural stem cells differentiation, pluripotency, reprogramming, and pluripotency. In the last decade, intensive studies were conducted to examine the role SOX2 has played in neural stem-cell maintenance and pluripotency. This article summarizes recent research on SOX2's role in neural stem-cell preservation. Its reactivity can be crucial for maintaining neural stem cell cells.
The Eph receptor family's largest Eph tyrosinekinase gene, SOX2, includes the SOX2 genes. Sox2 is involved in the development of neuronal differentiation within human embryonic neural stem cells. It also plays an important role in the development and maintenance the CNS, including the prevention from injury. The findings have broad implications in treating CNS disorders. NSCs possess a multipotency that allows them to repair and regenerate damaged tissues or neurons.
ESC establishment also depends on Sox2. It also lowers adult neurogenesis. ESCs are unable to grow normally within adult hippocampal tissue if SOX2 does not exist. This research is a perfect example of the benefits iPSCs have for regenerative medicines. The benefits of iPSCs cannot be overstated. Sox2 acts as the master regulator of stemness and is crucial for the establishment and maintenance of pluripotent ESCs.
The SOX2 Biomarker is a highly sensitive biomarker which can detect cancer stem cells as well as their potential transformation into tumors. SOX2 is expressed aberrantly in sporadic postmenopausal early breast cancers. This protein is thought to contribute to the formation of a cellular niche in the breast. However, SOX2 could be misused.
Variability of SOX2 expression has been found in various types of cancers and may be responsible for tumor physiology. This marker might be misleading, as SOX2 can only be expressed in tumor-initiating (cancer stem) cells. Because tumor cells are subsets of cells within a tumor tissue, the level SOX2 will likely vary. The benefits of using the SOX2 Marker to detect cancer stem cells are numerous.
Multiple mechanisms regulate Sox2 gene expression in tumors. These mechanisms will need to be studied in more detail in order to identify how SOX2 regulates gene transcription activity. Furthermore, the SOX2 function in different tissues is highly variable, which can lead to profound functional differences. The SOX2 Marker can help cancer researchers develop novel treatment strategies based on its expression level. SOX2 Marker has many benefits, including increased sensitivity and decreased sensitivity, as it can detect changes in the tumor's personality.
PMID: 7849401 by Stevanovic M., et al. The cDNA sequence and chromosomal location of the human SOX2 gene.
PMID: 12612584 by Fantes J., et al. Mutations in SOX2 cause anophthalmia.
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