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Facts about Tumor necrosis factor receptor superfamily member 17.
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL.
Promotes B-cell survival and plays a role in the regulation of humoral immunity.Activates NF-kappa-B and JNK. .
Human | |
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Gene Name: | TNFRSF17 |
Uniprot: | Q02223 |
Entrez: | 608 |
Belongs to: |
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No superfamily |
B cell maturation antigen; B-cell maturation protein; BCMA; BCMAtumor necrosis factor receptor superfamily member 17; BCMB-cell maturation factor; CD269 antigen; CD269; TNFRSF13A; TNFRSF17; tumor necrosis factor receptor superfamily, member 17
Mass (kDA):
20.165 kDA
Human | |
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Location: | 16p13.13 |
Sequence: | 16; NC_000016.10 (11965210..11968068) |
Expressed in mature B-cells, but not in T- cells or monocytes.
Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Perinuclear Golgi-like structures.
In this article, we'll discuss the TNFRSF17 biomarker and ELISA. This biomarker is well-known due to its high specificity and sensitivity. Boster's validation process will be discussed, including testing antibodies against positive or negative samples. Boster will award product credits to the first reviewer to review the product. Boster is always is grateful for the contribution of scientists from all over the globe.
BCMA is a member the TNF receptor superfamily. It is found in a variety of immune organs as well as B cell lines. BCMA is expressed on cells and appears to be localized within the Golgi compartment. It binds to BAFF and APRIL, stimulating the production of IgM in peripheral blood B cells. It could also stimulate IgA class-switching through T cell independent mechanisms.
TNFRSF17 belongs to the tumor necrosis family. Boster provides high-affinity, highly specific primary antibodies against this marker. These antibodies have been validated by multiple platforms, including Western Blotting, immunohistochemistry, and ELISA. Boster is dedicated to providing researchers with the best possible antibodies to fulfill their research needs. The company rewards researchers who review their products prior to others!
The Human Tissue Necrosis Factor Receptor Superfamily 17 (TNFRSF17) ELISA Kit is designed for quantitative analysis of human TNFRSF17 in the supernates of cell cultures or plasma. TNFRSF17 is a type III membrane protein located in the cell membrane and in the endomembrane system. It is prominently expressed in mature B cells however, it is not present in T-cells nor monocytes.
This human TNFRSF17 ELISA Kit is based on standard sandwich ELISA technology. The kit consists of a mouse monoclonal antibody specific for TNFRSF17. It is coated on 96-well plates. The next step is to add the test samples and the standards. Next is a goat biotinylated detector polyclonal antibody is inserted into the plates of 96 wells. After adding the standards and samples to the wells, the unbound conjugates are washed using PBS or TBS buffer. The HRP substrate TMB can be used to visualize the HRP enzyme reaction.
The TNFRSF17 ELISA Kit is highly specificity. Cross-reactivity cannot be detected with other relevant proteins. Samples should be diluted according to the end user preference and the appropriate levels. Each 96-well plate must remain at 37°C for at least 30 minutes. If the concentration of TNFRSF17 is higher than the set concentration, the sample must be diluted accordingly.
The TNFRSF17 protein is a member of the TNF-receptor superfamily. It is expressed most frequently in mature B lymphocytes. It could be essential in the development of B cells. It has also been shown to attach to tumor necrosis factors superfamily member 13b, which triggers activation of the NF-kappaB. Furthermore, TNFSF13B is believed to be a binder for various members of the TRAF family, which could trigger the transduction and transmission of signals to promote cell proliferation and survival.
PMID: 1396583 by Laabi Y., et al. A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma.
PMID: 8165126 by Laabi Y., et al. The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed.
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