TRAF6 Antibodies

TNF receptor-associated factor 6 (TRAF6)

Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN.

May be essential for the creation of functional osteoclasts.

Gene Information

Human
Gene Name:	TRAF6
Uniprot:	Q9Y4K3
Entrez:	7189

Family

Belongs to:
TNF receptor-associated factor family

Alternative Names

E3 ubiquitin-protein ligase TRAF6; EC 6.3.2.-; Interleukin-1 signal transducer; RING finger protein 85; RNF85MGC:3310; TNF receptor-associated factor 6; TRAF6; TRAF-6

Molecular Weight

Mass (kDA):
59.573 kDA

Genomic Context

Human
Location:	11p12
Sequence:	11; NC_000011.10 (36483769..36510313, complement)

Tissue Specificity

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Subcellular Localizations

Cytoplasm. Cytoplasm, cell cortex. Nucleus. Lipid droplet. Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity).

Diseases

• Inflammation
• Malignant Neoplasms
• Neoplasms
• Innate Immune Response
• Arthritis
• Autoimmune Reaction
• Inflammatory Response
• Autoimmune Diseases
• Rheumatoid Arthritis
• Virus Diseases
• Lymphoma
• Cell Transformation, Neoplastic
• Osteoporosis

• Tissue Adhesions
• Infective Disorder
• Autoimmunity
• Osteopenia
• Communicable Diseases
• Bacterial Infections
• Bone Diseases

Interacting Proteins

• CD40
• Ecsit
• EDA2R
• EDARADD
• IL1R1

• IRAK1
• IRAK2
• MALT1
• MAP3K14
• MAP3K7

• MAVS
• MEOX2
• Ngfr
• PLEKHF2
• POLI

• SPHK1
• SQSTM1
• TAB2
• TAX1BP1
• TIFA

• TNIK
• TRAF1
• TRAF2
• TRAF3IP2
• TRAF5

• UBC
• UBE2D1
• UBE2D2
• UBE2D3
• UBE2N

• ULK1
• USP2
• VPS52
• WDR5
• XIAP

• YES1
• ZNF675
• ZRANB1

Pathways

• Osteoclast Differentiation
• Immune Response
• Pathogenesis
• Secretion
• Bone Resorption
• Cytokine Production
• Inflammatory Response
• Cell Death
• Rna Interference
• Localization
• Cell Proliferation
• Innate Immune Response
• Cell Activation

• Autophagy
• Bone Remodeling
• Angiogenesis
• Viral Replication
• Cell Growth
• Cytokine Secretion
• Macrophage Activation

PTMs

• Phosphorylation
• Ubiquitination
• Cleavage
• Methylation
• Sumoylation
• Biotinylation
• Glutathionylation
• Oxidation

• Demethylation
• Nitrosylation
• Isgylation
• Deglutathionylation
• Ribosylation
• Deamidation
• Nitration
• Acetylation

• Myristoylation

Research Areas

• Immunology
• Innate Immunity
• Signal Transduction
• Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRAF6

Best Uses of the TRAF6 Marker

Boster Bio has many educational resources that emphasize the importance of the TRAF6 marker for the human body. These documents are available in PDF format, and they are available for free sharing with your students. It is essential to properly cite the resources and hyperlink them to their original sources. In order to make use of these resources, you must adhere to the Boster Bio guidelines. We hope that you enjoy this guide!

TRAF6 is an adaptor protein.

TRAF6 is an adaptor protein that is involved in a variety of interactions between proteins. Its RING finger and TRAF domains play significant roles in signal transduction, and it has been implicated in the activation of the phosphoinositide 3 kinase (PI3K) pathway as well as the activation of various other pathways. In addition to its function in organogenesis and immunity, TRAF6 may also play a crucial role in the regulation of messenger RNA.

The structure of TRAF6 is intricately linked to SARM1 and PINK1 which are involved in stabilizing PINK1 in the outer membrane of the cell , and in the activation of mitophagy. TRAF6 ubiquitinates PINK1 in a K63-linked way at lysine 433. TRAF6 also plays a significant role in the regulation and control of mitophagy, autophagy, and other processes.

TRAF6's TRAF6 ubiquitin binding domain binds the IRAK-1. This kinase plays a role in activation transcription factors. It also activates TAK1, which is a kinase that phosphorylates downstream Kinases including IKKb, MAPK and p38. The activation causes many different consequences in cells.

This adapter protein is involved in signaling pathways for the IL-1 receptor as well as the Toll-like receptor. TRAF6 interacts with IRAK1 and TRAF6 to boost IL-8 transcription. It activates IRF1, and is then responsible for the induction of IFN-beta. In addition, TRAF6 regulates the antimicrobial REG3G lectin.

TRAF6 is a member in the IRAK family of adaptor proteins. Its E3 activity is essential to activate the NF-kB pathway, whereas IRAK-1 doesn't not require TRAF6. The IRAK-1 gene is also part of the TAB2/TAB3 family. TRAF6 cDNA is purified from bacterial lysates by using GSH beads.

It regulates autophagy.

Autophagy is a pathophysiological process in eukaryotic cells that uses Lysosomes to remove damaged organelles as well as abnormal protein. An increase in autophagy activity has been linked with an increase in osteoclast differentiation. TRPV4 can boost autophagy-related proteins, and GSK2606414 is a PERK inhibitor, can hinder autophagy flow.

Autophagy is a very preserved eukaryotic recycling process which cells break down cytoplasmic organelles and recycle breakdown products. Autophagy is a vital aspect of cellular survival and contributes significantly to the development of many human diseases. However it is not fully understood. To better the understanding of autophagy, more research is needed to identify the precise roles of these cell-cycles.

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