TRAF6 Antibodies

AND TRAF6 ELISA kits, TRAF6 Proteins

Many biological assays use antibodies to detect TRAF6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRAF6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRAF6 antibodies...

We validate the specificity of these antibodies to TRAF6 by testing them on tissues known to express TRAF6 positively and negatively. Browse below to find the TRAF6 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TRAF6 Infographic by Boster Bio

All TRAF6 Products

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Product

Figures

Specificity

Applications

Price

Anti-TRAF6 Rabbit Monoclonal Antibody

All lanes use the Antibody at 1:3K dilution for 1 hour at room temperature

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$370
Cat # M00185-1
100 μl

Anti-TRAF6 Rabbit Monoclonal Antibody

11 Citations 3 Q&As

Western blot analysis of TRAF6 expression in Jurkat cell lysate

The regulatory effects of MOIG on NF-κB and JAK2/STAT3 pathway of TNF-α-stimulated FLSs cells

calpain2a interacts with TRAF6 and inhibits the NF-κB Signaling Pathway

Human, Mouse, Rat

IF, IHC, ICC, WB

$370
Cat # M00185
100 μl

Anti-TRAF6 Antibody Picoband®

10 Citations 1 Q&As

Western blot analysis of TRAF6 using anti-TRAF6 antibody (A00185)

IHC analysis of TRAF6 using anti-TRAF6 antibody (A00185)

Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A00185
100 μg/vial

Anti-TRAF6 Antibody

Western blot analysis of TRAF6 in PC-3 cell lysates with TRAF6 antibody at 1 μg/mL in the presence (A) or absence (B) of 1 μg blocking peptide

Immunocytochemistry of TRAF6 in K562 cells with TRAF6 antibody at 0

Immunofluorescence of TRAF6 in K562 cells with TRAF6 antibody at 20 μg/mL

Human, Mouse, Rat

ELISA, IF, ICC, WB

$481
Cat # A00185-1
0.1 mg

TRAF6 Overview

Facts about TNF receptor-associated factor 6.

TRAF6 3D structure. Source: alphafold

TNF receptor-associated factor 6 (TRAF6)

Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN.

May be essential for the creation of functional osteoclasts.

Gene Information

Human
Gene Name:	TRAF6
Uniprot:	Q9Y4K3
Entrez:	7189

Family

Belongs to:

TNF receptor-associated factor family

Alternative Names

E3 ubiquitin-protein ligase TRAF6; EC 6.3.2.-; Interleukin-1 signal transducer; RING finger protein 85; RNF85MGC:3310; TNF receptor-associated factor 6; TRAF6; TRAF-6

Molecular Weight

Mass (kDA):
59.573 kDA

Genomic Context


Human

Location:	11p12
Sequence:	11; NC_000011.10 (36483769..36510313, complement)

Tissue Specificity

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Subcellular Localizations

Cytoplasm. Cytoplasm, cell cortex. Nucleus. Lipid droplet. Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity).

Diseases

Inflammation
Malignant Neoplasms
Neoplasms
Innate Immune Response
Arthritis
Autoimmune Reaction
Inflammatory Response
Autoimmune Diseases
Rheumatoid Arthritis
Virus Diseases
Lymphoma
Cell Transformation, Neoplastic
Osteoporosis

Tissue Adhesions
Infective Disorder
Autoimmunity
Osteopenia
Communicable Diseases
Bacterial Infections
Bone Diseases

Interacting Proteins

CD40
Ecsit
EDA2R
EDARADD
IL1R1

IRAK1
IRAK2
MALT1
MAP3K14
MAP3K7

MAVS
MEOX2
Ngfr
PLEKHF2
POLI

SPHK1
SQSTM1
TAB2
TAX1BP1
TIFA

TNIK
TRAF1
TRAF2
TRAF3IP2
TRAF5

UBC
UBE2D1
UBE2D2
UBE2D3
UBE2N

ULK1
USP2
VPS52
WDR5
XIAP

YES1
ZNF675
ZRANB1

Pathways

Osteoclast Differentiation
Immune Response
Pathogenesis
Secretion
Bone Resorption
Cytokine Production
Inflammatory Response
Cell Death
Rna Interference
Localization
Cell Proliferation
Innate Immune Response
Cell Activation

Autophagy
Bone Remodeling
Angiogenesis
Viral Replication
Cell Growth
Cytokine Secretion
Macrophage Activation

PTMs

Phosphorylation
Ubiquitination
Cleavage
Methylation
Sumoylation
Biotinylation
Glutathionylation
Oxidation

Demethylation
Nitrosylation
Isgylation
Deglutathionylation
Ribosylation
Deamidation
Nitration
Acetylation

Myristoylation

Research Areas

Immunology
Innate Immunity
Signal Transduction
Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRAF6

References

PMID: 8837778 by Cao Z., et al. TRAF6 is a signal transducer for interleukin-1.

PMID: 9020361 by Malinin N.L., et al. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.

5 Publications of Boster TRAF6 Antibodies & ELISA Kits

PubMed ID: 10.12659/MSM.929438, Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4...
PubMed ID: 10.1128/IAI.00585-21, microRNA-20-1 and miR-101a suppress the NF-κB-mediated inflammation production ...
PubMed ID: 32855700, Liu L,Liu F,Sun Z,Peng Z,You T,Yu Z. LncRNA NEAT1 promotes apoptosis and inflamm...
PubMed ID: 25269519, Liu Mw, Wang Yh, Qian Cy, Li H. Int J Mol Med. 2014 Dec;34(6):1492-504. Doi: 10....
PubMed ID: 25202335, Yuan Z, Zhang J, Yang C. Evid Based Complement Alternat Med. 2014;2014:620359. D...

*More publications can be found for each product on its corresponding product page