Thioredoxin-interacting protein (TXNIP)

May act as an oxidative stress mediator by inhibiting thioredoxin action or by restricting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm.

Functions as a transcriptional repressor, perhaps by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.