Anti-TXNIP Antibody

Product Name

Anti-TXNIP Antibody

View all TXNIP Antibodies

SKU/Catalog Number

A01409

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-TXNIP Antibody (Catalog # A01409). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

TXNIP antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Cite This Product

Anti-TXNIP Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01409)

Host

Rabbit

Contents

TXNIP antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

TXNIP antibody was raised against a 16 amino acid peptide near the center of human TXNIP. The immunogen is located within amino acids 110 - 160 of TXNIP.

Cross-reactivity

TXNIP antibody is human, mouse and rat reactive.

Reactive Species

A01409 is reactive to TXNIP in Human, Mouse, Rat

Observed Molecular Weight

68 kDa

Calculated molecular weight

43.7 kDa

Background of TXNIP

Thioredoxin-interacting protein (TXNIP) belongs to the arrestin family and plays a critical role in the antioxidant defense mechanisms of hematopoietic cells by activating the p53 pathway during oxidative stress (1,2). It functions as a transcriptional repressor and acts as an oxidative stress mediator by inhibiting thioredoxin activity (2). TXNIP expression is reduced in many types of tumors, and TXNIP overexpression inhibits tumor growth by blocking cell-cycle progression (3). It has recently reported that TXNIP deficiency correlates with a high incidence of hepatocellular carcinoma (HCC) (4). TXNIP and p53 interactions could potentially be a therapeutic target for oxidative stress-related diseases such as hematopoietic malignancies and metabolic diseases (5).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A01409 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

TXNIP body can be used for detection of TXNIP by Western blot at 0.5 - 1 μg/ml. Antibody can also be used for Immunohistochemistry at 2 μg/mL. For Immunoflorescence start at 5 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

See full target information TXNIP

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