Zinc finger E-box-binding homeobox 1 (ZEB1)

Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression.

Enhances or represses the promoter activity of this ATP1A1 gene based on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and causes an epithelial-mesenchymal transition (EMT) by recruitment SMARCA4/BRG1.