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September 15, 2017
If you missed our Microbiology & Immunology virtual event this week, here are some additional resources relevant to the topics.
Click the meme below
for 12 more pathways!
IL-6 Receptor Pathway
Interleukin 6 receptor (also known as CD126) is encoded by the IL6R gene in humans. It is a type I cytokine receptor for Interleukin 6 (IL6), which is a potent pleiotropic cytokine. IL6 regulates cell growth and differentiation and plays an important role in immune response. The production of IL6 and this receptor are key processes that must be properly regulated. The pathogenesis of many autoimmune diseases, multiple myeloma, and even prostate cancer are affected by the functions of IL6 and IL6R. Furthermore, the IL6R protein subunit is also shared by many other cytokines. Interleukin-6 receptor has been shown to interact with ciliary neurotrophic factor as well. Click the pathway map to the right to see pathway details!
IL-18 Signaling Pathway
IL-18 is a proinflammatory cytokine that belongs to the IL-1 superfamily, and in humans is encoded by the IL-18 gene. It is produced by macrophages (and other cells), and works by binding to the interleukin-18 receptor. Working with IL-12, it induces cell-mediated immunity following infection. Apart from its physiological role, IL-18 is also able to induce severe inflammatory responses. This suggests it plays a role in various inflammatory disorders. For example, IL-18 is up regulated by interferon-gamma, and has been implicated as an inflammatory mediator of Hashimoto's thyroiditis (the most common cause of autoimmune hypothyroidism). In human neuron cells, IL-18 has also been found to increase the amyloid-beta production associated with Alzheimer's disease. Click the pathway map to the right to see pathway details!
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