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- Table of Contents
ADRA2A Antibodies
AND ADRA2A ELISA kits, ADRA2A Proteins
Many biological assays use antibodies to detect ADRA2A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ADRA2A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ADRA2A antibodies...
Designing a Western blot for ADRA2A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ADRA2A Western Blot GuideADRA2A Infographic by Boster Bio
All ADRA2A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$370
Cat # PA2197
100 μg/vial
Cat # PA2197
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00883-3
100 μg/vial
Cat # A00883-3
100 μg/vial
Human
$628
Cat # LS000150
20 µg, 100 µg
Cat # LS000150
20 µg, 100 µg
ADRA2A Overview
Facts about Alpha-2A adrenergic receptor.
Alpha-2A adrenergic receptor (ADRA2A)
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine.
For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ADRA2A |
| Uniprot: | P08913 |
| Entrez: | 150 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
a-2A AdrenergicR; ADRA2; ADRA2A; ADRA2Ralpha-2-adrenergic receptor, platelet type; ADRARZNF32; adrenergic, alpha-2A-, receptor; Alpha-2 adrenergic receptor subtype C10; alpha-2A Adrenergic R; alpha-2A adrenergic receptor; alpha2A AdrenergicR; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; alpha-2AAR subtype C10; ALPHA2AAR; Alpha-2AAR; ZNF32
Molecular Weight
Mass (kDA):
50.647 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q25.2 |
| Sequence: | 10; NC_000010.11 (111077029..111080907) |
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Attention Deficit Hyperactivity Disorder
- Depressive Disorder
- Hypertensive Disease
- Diabetes Mellitus
- Pertussis
- Nervousness
- Diabetes Mellitus, Non-insulin-dependent
- Pain
- Malnutrition
- Obesity
- Heart Failure
- Dysequilibrium Syndrome
Interacting Proteins
- ADRA2C
Pathways
- Secretion
- Insulin Secretion
- Platelet Aggregation
- Localization
- Reflex
- Glucose Homeostasis
- Cell Proliferation
- Transport
- Response To Methylphenidate
- Vasoconstriction
- Endocytosis
- Pathogenesis
- Synaptic Transmission
PTMs
- Phosphorylation
- Palmitoylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ADRA2A
bosterbio.com/bosterbio-gene-info-cards/ADRA2A
References
PMID: 2823383 by Kobilka B.K., et al. Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor.
PMID: 2568356 by Fraser C.M., et al. Cloning, sequence analysis, and permanent expression of a human alpha 2-adrenergic receptor in Chinese hamster ovary cells. Evidence for independent pathways of receptor coupling to adenylate cyclase attenuation and activation.
1 Publications of Boster ADRA2A Antibodies & ELISA Kits
- PubMed ID: 27805929, Genetic variant rs3750625 in the 3'UTR of ADRA2A affects stress-dependent acute ...
*More publications can be found for each product on its corresponding product page