Anti-alpha 2a Adrenergic Receptor/ADRA2A Antibody

alpha-2A Adrenergic R/ADRA2A antibody

Boster Bio Anti-alpha 2a Adrenergic Receptor/ADRA2A Antibody catalog # PA2197. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. Cited in 1 publication(s).

Product Info Summary

SKU: PA2197
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: WB

Product Name

Anti-alpha 2a Adrenergic Receptor/ADRA2A Antibody

View all alpha-2A Adrenergic R/ADRA2A Antibodies

SKU/Catalog Number

PA2197

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-alpha 2a Adrenergic Receptor/ADRA2A Antibody catalog # PA2197. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-alpha 2a Adrenergic Receptor/ADRA2A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA2197)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human alpha 2a Adrenergic Receptor, identical to the related mouse and rat sequences.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA2197 is reactive to ADRA2A in Human, Mouse, Rat

Applications

PA2197 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

50.647kDa

Background of alpha-2A Adrenergic R/ADRA2A

The alpha-2A adrenergic receptor, also known as ADRA2A denotes the human gene encoding it. This gene is mapped to 10q25.2. Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat

Validation Images & Assay Conditions

Gene/Protein Information For ADRA2A (Source: Uniprot.org, NCBI)

Gene Name

ADRA2A

Full Name

Alpha-2A adrenergic receptor

Weight

50.647kDa

Superfamily

G-protein coupled receptor 1 family

Alternative Names

a-2A AdrenergicR; ADRA2; ADRA2A; ADRA2Ralpha-2-adrenergic receptor, platelet type; ADRARZNF32; adrenergic, alpha-2A-, receptor; Alpha-2 adrenergic receptor subtype C10; alpha-2A Adrenergic R; alpha-2A adrenergic receptor; alpha2A AdrenergicR; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; alpha-2AAR subtype C10; ALPHA2AAR; Alpha-2AAR; ZNF32 ADRA2A ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32 adrenoceptor alpha 2A alpha-2A adrenergic receptor|adrenergic, alpha-2A-, receptor|alpha-2 adrenergic receptor subtype C10|alpha-2-adrenergic receptor, platelet type|alpha-2A adrenoceptor|alpha-2A adrenoreceptor|alpha-2AAR subtype C10

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on ADRA2A, check out the ADRA2A Infographic

ADRA2A infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for ADRA2A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

PA2197 has been cited in 1 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Genetic variant rs3750625 in the 3'UTR of ADRA2A affects stress-dependent acute pain severity after trauma and alters a microRNA-34a regulatory site.

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1 Customer Q&As for Anti-alpha 2a Adrenergic Receptor/ADRA2A Antibody

Question

We are currently using anti-alpha 2a Adrenergic Receptor/ADRA2A antibody PA2197 for human tissue, and we are satisfied with the WB results. The species of reactivity given in the datasheet says human, mouse, rat. Is it possible that the antibody can work on feline tissues as well?

Verified Customer

Verified customer

Asked: 2019-07-31

Answer

The anti-alpha 2a Adrenergic Receptor/ADRA2A antibody (PA2197) has not been validated for cross reactivity specifically with feline tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in feline you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2019-07-31

Size

Conjugation

Total: $370

SKU:PA2197

In stock, 1 left.

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$50 fee for conjugation. Antibody size is reduced to 50ug.

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