Anti-CALCOCO2 Antibody

Product Name

Anti-CALCOCO2 Antibody

View all NDP52 Antibodies

SKU/Catalog Number

A05876

Size

100ul

Form

Liquid

Description

Boster Bio Anti-CALCOCO2 Antibody catalog # A05876. Tested in WB,ICC/IF applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-CALCOCO2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05876)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human DLL3 protein.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A05876 is reactive to CALCOCO2 in Human, Mouse, Rat

Applications

A05876 is guaranteed for IF, ICC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

52.254kDa

Background of NDP52

Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.

Nagase T., DNA Res. 5:355-364(1998).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:500-1:2000
ICC/IF: 1:50-1:200

Validation Images & Assay Conditions

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Figure 1. Western blotting validation for Anti-CALCOCO2 Antibody A05876

Western blot analysis of extracts of various cell lines

Gene/Protein Information For CALCOCO2 (Source: Uniprot.org, NCBI)

Alternative Names

Antigen nuclear dot 52 kDa protein; calcium binding and coiled-coil domain 2; calcium-binding and coiled-coil domain-containing protein 2; NDP52MGC17318; Nuclear domain 10 protein 52; Nuclear domain 10 protein NDP52; Nuclear dot protein 52 CALCOCO2 NDP52 calcium binding and coiled-coil domain 2 calcium-binding and coiled-coil domain-containing protein 2|antigen nuclear dot 52 kDa protein|nuclear domain 10 protein 52|nuclear domain 10 protein NDP52|nuclear dot protein 52

For more info on CALCOCO2, check out the CALCOCO2 Infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CALCOCO2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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