Anti-Cdc16 (K556) Antibody

CDC16 antibody

Boster Bio Anti-Cdc16 (K556) Antibody catalog # A04573-2. Tested in IHC,IF applications. This antibody reacts with Human,Mouse,Rat.

Product Info Summary

SKU: A04573-2
Size: 100ul
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IF, IHC

Product Name

Anti-Cdc16 (K556) Antibody

View all CDC16 Antibodies

SKU/Catalog Number

A04573-2

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Cdc16 (K556) Antibody catalog # A04573-2. Tested in IHC,IF applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Cdc16 (K556) Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04573-2)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human THC2

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A04573-2 is reactive to CDC16 in Human, Mouse, Rat

Applications

A04573-2 is guaranteed for IF, IHC Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

71.656kDa

Background of CDC16

Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.

Ota T., Nat. Genet. 36:40-45(2004).
Deloukas P., Nature 429:375-381(2004).
Beausoleil S.A., Nat. Biotechnol. 24:1285-1292(2006).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

IHC: 1:50-1:200
IF: 1:50-1:200

Validation Images & Assay Conditions

Gene/Protein Information For CDC16 (Source: Uniprot.org, NCBI)

Gene Name

CDC16

Full Name

Cell division cycle protein 16 homolog

Weight

71.656kDa

Superfamily

APC6/CDC16 family

Alternative Names

ANAPC6subunit 6; CDC16 (cell division cycle 16, S. cerevisiae, homolog); CDC16 cell division cycle 16 homolog (S. cerevisiae); CDC16 homolog; CDC16Hs; cell division cycle 16 homolog (S. cerevisiae); cell division cycle protein 16 homolog; Cyclosome subunit 6 CDC16 ANAPC6, APC6Hs, CUT9, CDC16 cell division cycle 16 cell division cycle protein 16 homolog|anaphase-promoting complex, subunit 6|cell division cycle 16 homolog|cyclosome subunit 6

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on CDC16, check out the CDC16 Infographic

CDC16 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CDC16: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A04573-2-100ul

100ul

$405

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