Anti-FIP1L1 Antibody Picoband™

FIP1L1 antibody

Boster Bio Anti-FIP1L1 Antibody Picoband™ catalog # A02452-1. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: A02452-1
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: ELISA, Flow Cytometry, IF, IHC, ICC, WB

Product Name

Anti-FIP1L1 Antibody Picoband™

View all FIP1L1 Antibodies

SKU/Catalog Number

A02452-1

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-FIP1L1 Antibody Picoband™ catalog # A02452-1. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Cite This Product

Anti-FIP1L1 Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02452-1)

Host

Rabbit

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

E.coli-derived human FIP1L1 recombinant protein (Position: E23-E558).

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A02452-1 is reactive to FIP1L1 in Human, Mouse, Rat

Applications

A02452-1 is guaranteed for ELISA, Flow Cytometry, IF, IHC, ICC, WB Boster Guarantee

Background of FIP1L1

Factor interacting with PAPOLA and CPSF1 (i.e, FIP1L1; also termed Pre-mRNA 3'-end-processing factor FIP1) is a protein that in humans is encoded by the FIP1L1 gene (also known as Rhe, FIP1, and hFip1). This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.

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Reconsitution

Adding 0.2 ml of distilled water will yield a concentration of 500 µg/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.

Western blot, 0.25-0.5 µg/ml, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 µg/ml, Human
Immunocytochemistry/Immunofluorescence, 5 µg/ml, Human
Flow Cytometry, 1-3 µg/1x106 cells, Human
Direct ELISA, 0.1-0.5 µg/ml, Human

Validation Images & Assay Conditions

Gene/Protein Information For FIP1L1 (Source: Uniprot.org, NCBI)

Uniprot ID

Q6UN15

Gene ID

81608

Gene Name

FIP1L1

Full Name

Pre-mRNA 3'-end-processing factor FIP1

Weight

66.526kDa

Superfamily

FIP1 family

Alternative Names

DKFZp586K0717; EC 1.1.1.86; EC 4.2.1.33; Factor interacting with PAP; FIP1 like 1 (S. cerevisiae); FIP1; FIP1-like 1 protein; FLJ33619; hFip1; pre-mRNA 3'-end-processing factor FIP1; Rearranged in hypereosinophilia; Rhe FIP1L1 FIP1, Rhe, hFip1 factor interacting with PAPOLA and CPSF1 pre-mRNA 3-end-processing factor FIP1|FIP1 like 1|FIP1-like 1 protein|FIP1L1 cleavage and polyadenylation specific factor subunit|factor interacting with PAP|rearranged in hypereosinophilia

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on FIP1L1, check out the FIP1L1 Infographic

FIP1L1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for FIP1L1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected]

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Total: $315

SKU:A02452-1

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A02452-1
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$315.00

$50 fee for conjugation. Antibody size is reduced to 50ug.

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