Anti-Hu CD120a Purified TNFRSF1A Monoclonal Antibody

Product Name

Anti-Hu CD120a Purified TNFRSF1A Monoclonal Antibody

View all TNF RI/TNFRSF1A Antibodies

SKU/Catalog Number

M00294

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Hu CD120a Purified TNFRSF1A Monoclonal Antibody (Catalog# M00294). Tested in Flow Cytometry, IP, IHC-P, IHC-F application(s). This antibody reacts with Human.

Storage & Handling

Store at 2-8°C. Do not freeze.

Cite This Product

Anti-Hu CD120a Purified TNFRSF1A Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00294)

Host

Mouse

Contents

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Clonality

Monoclonal

Clone Number

H398

Isotype

Mouse IgG2a

Immunogen

Recombinant full length human CD120a. The mouse monoclonal antibody H398 recognizes the extracellular domain of CD120a, a 55 kDa receptor for tumor necrosis factor. The antibody blocks biological activity of both natural and recombinant human TNF alpha and TNF beta.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M00294 is reactive to TNFRSF1A in Human

Applications

M00294 is guaranteed for Flow Cytometry, IP, IHC-P, IHC-F Boster Guarantee

Observed Molecular Weight

42 kDa

Calculated molecular weight

50.495kDa

Background of TNF RI/TNFRSF1A

CD120a / TNF R1, also known as TNFR55 or TNFRSF1A, is a 55 kDa receptor for tumor necrosis factor alpha and it is expressed in most tissues. By binding its trimeric ligand the CD120a protein forms trimers and the conformation change leads to dissociation of the inhibitory factor SODD from its intracellular death domain and in formation of signaling platform. CD120a can mediate apoptosis, and function as a regulator of inflammation. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Flow cytometry: 1-4 μg/ml.

Validation Images & Assay Conditions

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Figure 1. Flow Cytometry validation of TNFRSF1A using Anti-Hu CD120a Purified TNFRSF1A Monoclonal Antibody (M00294).

Flow cytometry analysis (surface staining) of CD120a in human peripheral blood with anti-human CD120a (H398) purified

Gene/Protein Information For TNFRSF1A (Source: Uniprot.org, NCBI)

Alternative Names

CD120a antigen; CD120a; FPF; p55; p55-R; p60; TNF RI; TNFARMGC19588; TNF-R; TNF-R1; TNFR1TBP1; TNFR55; TNF-R55; TNFR60; TNFRI; TNF-RI; TNF-R-I; TNFR-I; TNFRSF1A; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor 1; tumor necrosis factor receptor 1A isoform beta; tumor necrosis factor receptor superfamily member 1A; tumor necrosis factor receptor superfamily, member 1A; tumor necrosis factor receptor type 1; Tumor necrosis factor receptor type I; tumor necrosis factor-alpha receptor TNFRSF1A CD120a, FPF, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR55, TNFR60, p55, p55-R, p60 TNF receptor superfamily member 1A tumor necrosis factor receptor superfamily member 1A|TNF-R1|TNF-RI|TNFR-I|tumor necrosis factor binding protein 1|tumor necrosis factor receptor type 1|tumor necrosis factor-alpha receptor

For more info on TNFRSF1A, check out the TNFRSF1A Infographic

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In this infographic, you will see the following information for TNFRSF1A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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