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Product Info Summary
| SKU: | M00366-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | Flow Cytometry, ICC |
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Product info
Product Name
Anti-Hu CD140a Purified PDGFRA Monoclonal Antibody
SKU/Catalog Number
M00366-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Hu CD140a Purified PDGFRA Monoclonal Antibody (Catalog# M00366-1). Tested in Flow Cytometry, ICC application(s). This antibody reacts with Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-Hu CD140a Purified PDGFRA Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00366-1)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
16A1
Isotype
Mouse IgG1 kappa
Immunogen
CD140a-transfected NIH 3T3 cells. The mouse monoclonal antibody 16A1 recognizes an extracellular epitope of CD140a / PDGF-RA, the 170 kDa alpha chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative or anti-proliferative roles in various tumours.
Reactive Species
M00366-1 is reactive to PDGFRA in Human
Observed Molecular Weight
42 kDa
Calculated molecular weight
122.7 kDa
Background of PDGFRA
CD140a / PDGF-RA (platelet-derived growth factor receptor alpha) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140a forms homodimers, or heterodimerizes with CD140b / PDGF-RB. Whereas CD140b induces in different cell types their proliferation and migration, the role of CD140a is more controversial, with pro-proliferative or anti-proliferative effects. CD140a has early developmental functions, mediates mesodermal cell migration, and later acts in signaling associated in epithelial-mesenchymal interactions.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M00366-1 is guaranteed for Flow Cytometry, ICC Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow cytometry: 2 μg/ml.
Validation Images & Assay Conditions
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Separation of cells stained using anti-human CD140a (16A1) purified antibody (concentration in sample 0,33 µg/ml, GAM APC, red-filled) from cells unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining) of CD140a transfected cell suspension.
Specific Publications For Anti-Hu CD140a Purified PDGFRA Monoclonal Antibody (M00366-1)
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