Anti-NTAL Purified LAT2 Monoclonal Antibody

Product Name

Anti-NTAL Purified LAT2 Monoclonal Antibody

View all LAT2 Antibodies

SKU/Catalog Number

M02496

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-NTAL Purified LAT2 Monoclonal Antibody (Catalog# M02496). Tested in IP, WB, IHC-P application(s). This antibody reacts with Human.

Storage & Handling

Store at 2-8°C. Do not freeze.

Cite This Product

Anti-NTAL Purified LAT2 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M02496)

Host

Mouse

Contents

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Clonality

Monoclonal

Clone Number

NAP-03

Isotype

Mouse IgG2a

Immunogen

Peptide corresponding to aa 196-212 of human NTAL coupled to KLH. The antibody NAP-03 recognizes a defined intracellular epitope (aa 196-212) of human Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 30 kDa transmembrane adaptor protein associating with lipid raft components in the plasma membrane of B cells, NK cells and myeloid cells.

Cross-reactivity

This antibody does not cross-react with Thy-1.1 alloantigen.

Reactive Species

M02496 is reactive to LAT2 in Human

Observed Molecular Weight

42 kDa

Calculated molecular weight

26.6 kDa

Background of LAT2

NTAL (non-T cell activation linker), also known as LAB (linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

M02496 is guaranteed for IP, IHC-P, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (paraffin sections): 5 μg/ml; positive tissue: tonsil, germinal center.
Western blotting: 1-2 μg/ml, incubation 60 min; positive control: RAMOS human lymphoma cell line; non-reducing conditions, 12% separating SDS-PAGE gel.

Validation Images & Assay Conditions

There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.

See full target information LAT2

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