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- Table of Contents
STAT3 Antibodies
AND STAT3 ELISA kits, STAT3 Proteins
Many biological assays use antibodies to detect STAT3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with STAT3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop STAT3 antibodies...
Designing a Western blot for STAT3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the STAT3 Western Blot GuideDesigning an IHC experiment for STAT3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the STAT3 IHC GuideSTAT3 Infographic by Boster Bio
All STAT3 Products
Product
Figures
Specificity
Applications
Price
Anti-STAT3 Antibody Picoband®
26 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9511
100 μg/vial
Cat # PB9511
100 μg/vial
Anti-Phospho-STAT3 (Y705) Rabbit Monoclonal Antibody
38 Citations
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # P00007-2
100 μl
Cat # P00007-2
100 μl
Anti-STAT3 Rabbit Monoclonal Antibody
30 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00007
100 μl
Cat # M00007
100 μl
Anti-Phospho-STAT3 (S727) Rabbit Monoclonal Antibody
11 Citations
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # P00007-1
100 μl
Cat # P00007-1
100 μl
Anti-STAT3 Rabbit Monoclonal Antibody
2 Citations
Human
IP, IF, IHC, ICC, WB
$370
Cat # M00007-2
100 μl
Cat # M00007-2
100 μl
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00007-1
100 μl
Cat # M00007-1
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00007-4
20μL, 40μL, 100μL, 200μL
Cat # M00007-4
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA
$540
Cat # EKC2516
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2516
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2515
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2515
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1543
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1543
1 kit, containing one 96-well plate and all necessary reagents
Functional Assay
$5040
Cat # RC1014
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO.
Cat # RC1014
1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO.
STAT3 Overview
Facts about Signal transducer and activator of transcription 3.
Signal transducer and activator of transcription 3 (STAT3)
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once triggered, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214).
May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225).
Gene Information
| Human | |
|---|---|
| Gene Name: | STAT3 |
| Uniprot: | P40763 |
| Entrez: | 6774 |
Family
| Belongs to: |
|---|
| transcription factor STAT family |
Alternative Names
Acute-phase response factor; APRFMGC16063; DNA-binding protein APRF; FLJ20882; HIES; signal transducer and activator of transcription 3 (acute-phase responsefactor); signal transducer and activator of transcription 3; STAT3
Molecular Weight
Mass (kDA):
88.068 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.2 |
| Sequence: | 17; NC_000017.11 (42313324..42388502, complement) |
Tissue Specificity
Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Subcellular Localizations
Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
Diseases
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Carcinoma
- Leukemia
- Cell Transformation, Neoplastic
- Janiceps
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Liver Carcinoma
- Tumor Angiogenesis
- Malignant Neoplasm Of Breast
Interacting Proteins
- BCKDK
- BICD1
- BLK
- BMX
- CAPN1
- CDK9
- CORO1A
- CSF3R
- DAXX
- DIRAS3
Pathways
- Cell Proliferation
- Pathogenesis
- Cell Growth
- Cell Cycle
- Secretion
- Cell Death
- Angiogenesis
- Regeneration
- Localization
- Cell Differentiation
- Immune Response
- Inflammatory Response
- Cell Migration
PTMs
- Phosphorylation
- Cleavage
- Methylation
- Acetylation
- Dephosphorylation
- Oxidation
- Reduction
- Demethylation
- Glycosylation
- Ubiquitination
Research Areas
- Cellular Markers
- Signal Transduction
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STAT3
bosterbio.com/bosterbio-gene-info-cards/STAT3
References
PMID: 7512451 by Akira S., et al. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91- related transcription factor involved in the gp130-mediated signaling pathway.
PMID: 9630560 by Della Pietra L., et al. Highly conserved amino-acid sequence between murine STAT3 and a revised human STAT3 sequence.
19 Publications of Boster STAT3 Antibodies & ELISA Kits
- PubMed ID: 10.1177/0300060519895353, Saturated hydrogen alleviates CCl4-induced acute kidney injury via JAK2/STAT3/p6...
- PubMed ID: 30747218, Zhang T,Ma L,Wu P,Li W,Li T,Gu R,Dan X,Li Z,Fan X,Xiao Z.Gallic acid has antican...
- PubMed ID: 33152901, He J,Zhang W,Di T,Meng J,Qi Y,Li G,Zhang Y,Su H,Yan W.Water extract of sporoderm...
- PubMed ID: 33542641, Zhang Q,Duan HX,Li RL,Sun JY,Liu J,Peng W,Wu CJ,Gao YX. Inducing Apoptosis and S...
- PubMed ID: 28065778, Protective effects of Tongxinluo on cerebral ischemia/reperfusion injury related...
- PubMed ID: 28808419, Exposure to Concentrated Ambient Fine Particulate Matter Induces Vascular Endoth...
- PubMed ID: 26549519, IL-6 Inhibits Starvation-induced Autophagy via the STAT3/Bcl-2 Signaling Pathway
- PubMed ID: 23463096, Delivery of the co-expression plasmid pEndo-Si-Stat3 by attenuatedSalmonellasero...
- PubMed ID: 20003295, The effects of HIF-1alpha on gene expression profiles of NCI-H446 human small ce...
- PubMed ID: 26959884, Prognostic role of STAT3 in solid tumors: a systematic review and meta-analysis
- PubMed ID: 23693134, Hu T, Zhang C, Tang Q, Su Y, Li B, Chen L, Zhang Z, Cai T, Zhu Y. Bmc Cancer. 20...
- PubMed ID: 23593080, Chen Y, Wang J, Wang X, Liu X, Li H, Lv Q, Zhu J, Wei B, Tang Y. J Breast Cancer...
- PubMed ID: 25695729, Wan J, Che Y, Kang N, Wu W. Mol Med Rep. 2015 Jul;12(1):83-92. Doi: 10.3892/Mmr....
- PubMed ID: 24519067, Zhang B, Lu Z, Hou Y, Hu J, Wang C. Tumour Biol. 2014 Jun;35(6):5401-7. Doi: 10....
- PubMed ID: 17392578, Hu Cp, Feng Jt, Tang Yl, Zhu Jq, Lin Mj, Yu Me. Mediators Inflamm. 2006;2006(5):...
- PubMed ID: 22938476, Zhao X, Sun X, Li Xl. Asian Pac J Cancer Prev. 2012;13(6):2873-7. Expression And...
- PubMed ID: 24789581, Zheng Q, Liu Y, Liu W, Ma F, Zhou Y, Chen M, Chang J, Wang Y, Yang G, He G. Mol ...
- PubMed ID: 23533997, Khan M, Li T, Ahmad Khan Mk, Rasul A, Nawaz F, Sun M, Zheng Y, Ma T. Biomed Res ...
- PubMed ID: 24228108, Li K, Zhu Zc, Liu Yj, Liu Jw, Wang Ht, Xiong Zq, Shen X, Hu Zl, Zheng J. Int J C...
*More publications can be found for each product on its corresponding product page