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Product Info Summary
| SKU: | A00007-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-STAT3 Antibody
SKU/Catalog Number
A00007-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-STAT3 Antibody (Catalog # A00007-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
STAT3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-STAT3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00007-1)
Host
Rabbit
Contents
STAT3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Rabbit polyclonal STAT3 antibody was raised against a 19amino acid peptide near the amino terminus of human STAT3. The immunogen is located within amino acids 170 - 220 of STAT3.
Reactive Species
A00007-1 is reactive to STAT3 in Human, Mouse, Rat
Observed Molecular Weight
68 kDa
Calculated molecular weight
88.1 kDa
Background of STAT3
STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6), STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT3 signals are pivotal to the proliferation and differentiation of neural stem cells and also participate in neuronal regeneration and cancers of the nervous system.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00007-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
STAT3 antibody can be used for detection of STAT3 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of STAT3 in human small intestine tissue lysate with STAT3 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of STAT3 in human small intestine tissue with STAT3 antibody at 5 μg/ml.
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Immunofluorescence of STAT3 in human small intestine tissue with STAT3 antibody at 20 μg/ml.
Specific Publications For Anti-STAT3 Antibody (A00007-1)
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