Angiopoietin-1 (ANGPT1)

Binds and activates TEK/TIE2 receptor by causing its dimerization and tyrosine phosphorylation. Plays an essential role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence.

Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context.