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- Table of Contents
BNIP3 Antibodies
AND BNIP3 ELISA kits, BNIP3 Proteins
Many biological assays use antibodies to detect BNIP3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BNIP3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BNIP3 antibodies...
Designing an IHC experiment for BNIP3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the BNIP3 IHC GuideBNIP3 Infographic by Boster Bio
All BNIP3 Products
Product
Figures
Specificity
Applications
Price
Anti-BNIP3L/Nix Rabbit Monoclonal Antibody
4 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # M03107
100 μl
Cat # M03107
100 μl
Anti-BNIP3 Rabbit Monoclonal Antibody
3 Citations
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M01469
100 μl
Cat # M01469
100 μl
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # A03107-3
100 μg/vial
Cat # A03107-3
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M01469-2
100 μl/vial
Cat # M01469-2
100 μl/vial
BNIP3 Overview
Facts about BCL2/adenovirus E1B 19 kDa protein-interacting protein 3.
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)
Apoptosis-inducing protein that may overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2.
Involved in mitochondrial quality control through its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) resulting in the degradation of damaged proteins within mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX in the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins in the cytoplasm to the mitochondrial matrix.
Gene Information
| Human | |
|---|---|
| Gene Name: | BNIP3 |
| Uniprot: | Q12983 |
| Entrez: | 664 |
Family
| Belongs to: |
|---|
| NIP3 family |
Alternative Names
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BCL2/adenovirus E1B 19kDa interacting protein 3; BCL2/adenovirus E1B 19kD-interacting protein 3; BNIP3; Nip3
Molecular Weight
Mass (kDA):
22 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q26.3 |
| Sequence: | 10; NC_000010.11 (131967683..131982013, complement) |
Subcellular Localizations
Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane.
Diseases
- Hypoxia
- Malignant Neoplasms
- Neoplasms
- Anoxia
- Carcinoma
- Ischemia
- Tumor Angiogenesis
- Adenocarcinoma
- Malignant Neoplasm Of Breast
- Malignant Paraganglionic Neoplasm
- Mammary Neoplasms
- Neoplasm Metastasis
Interacting Proteins
- BNIP3L
- CLEC7A
- FATE1
- KTN1
- LDLRAD1
- OPA1
- PPTC7
- TMEM11
Pathways
- Cell Death
- Autophagy
- Methylation
- Angiogenesis
- Localization
- Cell Cycle
- Response To Hypoxia
- Pathogenesis
- Programmed Cell Death
- Autophagic Cell Death
- Dna Methylation
- Glycolysis
- Cell Proliferation
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Demethylation
- Deacetylation
- Hydroxylation
- Ubiquitination
Research Areas
- Apoptosis
- Autophagy
- Cancer
- Hypoxia
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BNIP3
bosterbio.com/bosterbio-gene-info-cards/BNIP3
References
PMID: 9396766 by Chen G., et al. The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis.
PMID: 7954800 by Boyd J.M., et al. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins.
3 Publications of Boster BNIP3 Antibodies & ELISA Kits
- PubMed ID: 10.1080/15548627.2020.1728096, Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington dise...
- PubMed ID: 33716067, Zhao YC,Guo W,Gao BH. Hypoxic training upregulates mitochondrial turnover and an...
- PubMed ID: 28977881, Du Y, Li J, Xu T, Zhou DD, Zhang L, Wang X. Oncotarget. 2017 Jun 22;8(37):61510-...
*More publications can be found for each product on its corresponding product page