Dynamin-1-like protein (DNM1L)

Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism.

The specific recruiting at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes (PubMed:29899447). While the recruitment from the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation in the receptors and allows DNM1L filaments to float into closed rings that are probably enough to sever a double membrane (PubMed:29899447).