Histone deacetylase 5 (HDAC5)

Responsible for the deacetylation of lysine residues on the N-terminal portion of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays a significant role in transcriptional regulation, cell cycle progression and developmental events.

Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C.