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- Table of Contents
Facts about Histone deacetylase 5.
Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C.
Human | |
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Gene Name: | HDAC5 |
Uniprot: | Q9UQL6 |
Entrez: | 10014 |
Belongs to: |
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histone deacetylase family |
Antigen NY-CO-9; EC 3.5.1.98; FLJ90614; HD5; histone deacetylase 5; KIAA0600; NY-CO-9
Mass (kDA):
121.978 kDA
Human | |
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Location: | 17q21.31 |
Sequence: | 17; NC_000017.11 (44076753..44123651, complement) |
Ubiquitous.
Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1.
The HDAC5 marker is a promising therapeutic target in the fight against cancer. Boster Bio provides high-sensitivity ELISA kits to determine the concentration of this protein in blood and tissue samples. Steven Boster, the founder of Boster Bio, was nicknamed "The man who transforms science into a toilet".
Boster Bio's HDAC5 marker-RTqPCR kit is an accurate method for determining the expression of genes in cancer line cells. By using RT2 Profiler PCR Arrays, researchers can analyze over 170 different pathways in just three steps. Mix the cDNA template and mastermix. Then, aliquot the mixture to each well. Then, use a live cycler for PCR to determine gene expression. This kit is compatible with Stratagene, Eppendorf, and QIAGEN. It employs an DDCT method for normalizing data to housekeeping genes.
The RT-qPCR array has been designed for the study of changes in the abundance of transcripts of 41 human genes in cellular pathways that are crucial to. It was created with 100-well discs which are compatible with the Rotor-Gene 6000 instrument. However it can be easily transformed to standard plates with 96 wells. It was equipped with several technical controls to assess the results. Six wells were used as a control group. They did not contain any templates or genes that could cause contamination. The housekeeping genes were amplified in six wells.
Using the Boster Bio HDAC5 marker RTqPCR, researchers were able to determine the amount of HDAC5 present in human fibroblast cells. The IL-1b receptor blocks ADAMTS expression and also stimulates rACs. Treatment with IL-1b inhibits ADAMTS and thus reduces inflammation in these cells. Similar results were seen in patients with AIDS.
Researchers are currently investigating the significance of HDAC inhibitors in OA pathogenesis. The inhibitors affect MAPK pathways and downregulate markers associated with OA. However, it isn't clear whether HDAC inhibitors are beneficial for OA treatment. These studies will provide important insights to the development and testing of anti-OA medications. These studies may also be used in the development of new tests for diagnosing the condition in the near future.
This HDAC inhibitor is very active in the brain. It binds to ubiquitinated proteins. This inhibitor blocks the ubiquitination of these proteins, which can influence brain development. It also regulates gene expression through binding to the ubiquitinated proteins. Boster Bio HDAC5 marker-qPCR kits can be used with many types of cancer cell lines.
The HDAC5 marker is a vital genetic marker that plays a key role in the cancer biology. It is present in a variety of tissues, including the brain. Boster Bio has a proprietary technology platform that enables it to make highly sensitive and specific ELISA kits for a variety of research applications. Boster Bio's proprietary technology platform has been tested for its quality and reproducibility. It comes with a variety of tools that give researchers and healthcare professionals the ability to measure HDAC5 levels as well as other chromatography-based markers.
The tbx3 mutant molecular structure contains a DNA binding domain however it lacks the motifs that interact with HDAC5. Therefore, it is not able to recruit itself to EDAC5 promoters making it a significant anti-cancer target. This study suggests that HDAC5 is an crucial gene in human cancer and its role in its regulation is vital in its research.
Inhibition of HDACs has potential as a treatment strategy for a range of ailments. It can alter the delicate balance between anti-inflammatory and blood factors, as well as the production and distribution of the soluble factors. The inhibition of HDACs could alter the functions of other immune cells like CD8 T cells.
HDAC inhibition is an attractive option for treating cancer. Studies have demonstrated that patients suffering from SCLC can respond better to HDAC inhibitors when paired with other DNA-damaging medications. Furthermore, cancer cells with lower levels of DNA strands and higher rates of late apoptosis are more likely respond to the treatment. TNBC is a very aggressive and unresponsive type of cancer, could be treated by HDAC inhibition.
Inhibition of HDACs inhibits the production of proinflammatory cytokines in APCs and stimulates a range of genes in lymphocytes that are effectors. Memory CD8T cells from murine can only produce IFN-g if they receive support from CD4 T cells. PanHDAC inhibitors have also been found to bring back the function of the depleted T cells in chronic viral infection. Although this is encouraging but it's still in the early stages to draw conclusions.
The role played by CD8 T cells in antitumor immunity is well known. HDAC inhibitors can enhance the function of this crucial subset. A recent study of the panHDAC inhibitor Panobinostat showed increased IFN-g and TNF-a levels. The inhibitor also increased the incidence of graft-versus-host disease. The study concluded that HDAC inhibition is a promising therapeutic approach for various cancers.
HDAC inhibitors have a distinct chemical structure. This allows them to have different effects on cancer cells and on normal cells. It can also affect the activity of many genes and proteins, which could lead to the process of apoptosis. But, despite the possible benefits of inhibiting HDACs there are many questions about the function of this inhibitor in treating cancer.
If you're curious about the life of Steve Boster, you're in good company! You can search through his public records to view his full address history, his previous addresses and even email addresses. You can also find out whether Steve Boster has any known relatives. You can also filter your search by state and age to find out more specific details about Steve. And because Steve was so generous, you can read his biography right on this website!
Steve Boster, the beloved child of Evelyn Meier, and James Boster died on June 6, 2022. He was a successful retail sales manager for many years, and was a member of Concordia Hall, Staunton, VA. Steve is survived by his wife, Natosha, and his two daughters, Crystal and Jack Boster. He also leaves behind 6 grandchildren, 4 brothers , and 2 sisters, Sandra Blanton and Sandra Blanton. He is survived by many of his family members and countless nieces and nephews.
PMID: 10220385 by Grozinger C.M., et al. Three proteins define a class of human histone deacetylases related to yeast Hda1p.
PMID: 9610721 by Scanlan M.J., et al. Characterization of human colon cancer antigens recognized by autologous antibodies.