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- Table of Contents
Facts about Interferon-induced transmembrane protein 3.
May inactivate new enveloped viruses that buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV).
Human | |
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Gene Name: | IFITM3 |
Uniprot: | Q01628 |
Entrez: | 10410 |
Belongs to: |
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CD225/Dispanin family |
1-8U; Fragilis; IFITM3; interferon induced transmembrane protein 3 (1-8U); interferon-induced transmembrane protein 3; Interferon-inducible protein 1-8U; IP15; mil-1
Mass (kDA):
14.632 kDA
Human | |
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Location: | 11p15.5 |
Sequence: | 11; NC_000011.10 (319676..320860, complement) |
Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein.
PMID: 1906403 by Lewin A.R., et al. Molecular analysis of a human interferon-inducible gene family.
PMID: 22446628 by Everitt A.R., et al. IFITM3 restricts the morbidity and mortality associated with influenza.