Anti-IFITM3 Antibody (N-term)

Product Name

Anti-IFITM3 Antibody (N-term)

View all IFITM3/Fragilis Antibodies

SKU/Catalog Number

M02265-1

Size

50 µl

Description

Boster Bio Anti-IFITM3 Antibody (N-term) (Catalog # M02265-1). Tested in WB application(s). This antibody reacts with Human.

Storage & Handling

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Cite This Product

Anti-IFITM3 Antibody (N-term) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M02265-1)

Host

Mouse

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Clonality

Monoclonal

Clone Number

1082CT14.1.3.1

Isotype

IgG1,k

Immunogen

This IFITM3 antibody is generated from a mouse immunized with a recombinant protein KLH conjugated synthetic peptide between 1-133 amino acids from the N-terminal region of human IFITM3.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M02265-1 is reactive to IFITM3 in Human

Reconstitution

Calculated molecular weight

14632 Da

Background of IFITM3/Fragilis

IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2- mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

M02265-1 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:4000

Validation Images & Assay Conditions

Gene/Protein Information For IFITM3 (Source: Uniprot.org, NCBI)

Alternative Names

Interferon-induced transmembrane protein 3, Dispanin subfamily A member 2b, DSPA2b, Interferon-inducible protein 1-8U, IFITM3 IFITM3 1-8U, DSPA2b, IP15 interferon induced transmembrane protein 3 interferon-induced transmembrane protein 3|dispanin subfamily A member 2b|interferon-inducible protein 1-8U

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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