Product Info Summary
SKU: | M02265-1 |
---|---|
Size: | 50 µl |
Reactive Species: | Human |
Host: | Mouse |
Application: | WB |
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Product info
Product Name
Anti-IFITM3 Antibody (N-term)
View all IFITM3/Fragilis Antibodies
SKU/Catalog Number
M02265-1
Size
50 µl
Description
Boster Bio Anti-IFITM3 Antibody (N-term) (Catalog # M02265-1). Tested in WB application(s). This antibody reacts with Human.
Storage & Handling
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Cite This Product
Anti-IFITM3 Antibody (N-term) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M02265-1)
Host
Mouse
Contents
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Clonality
Monoclonal
Clone Number
1082CT14.1.3.1
Isotype
IgG1,k
Immunogen
This IFITM3 antibody is generated from a mouse immunized with a recombinant protein KLH conjugated synthetic peptide between 1-133 amino acids from the N-terminal region of human IFITM3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
M02265-1 is reactive to IFITM3 in Human
Reconstitution
Calculated molecular weight
14632 Da
Background of IFITM3/Fragilis
IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2- mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M02265-1 is guaranteed for WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:4000
Validation Images & Assay Conditions
Click image to see more details
All lanes : Anti-Fragilis (IFITM3) Antibody (N-term) at 1:4000 dilution
Lane 1: NCI-H460 whole cell lysate
Lane 2: HepG2 whole cell lysate
Lysates/proteins at 20 µg per lane.
Secondary
Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.
Predicted band size : 15 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.
Protein Target Info & Infographic
Gene/Protein Information For IFITM3 (Source: Uniprot.org, NCBI)
Gene Name
IFITM3
Full Name
Interferon-induced transmembrane protein 3
Weight
14632 Da
Superfamily
CD225/Dispanin family
Alternative Names
Interferon-induced transmembrane protein 3, Dispanin subfamily A member 2b, DSPA2b, Interferon-inducible protein 1-8U, IFITM3 IFITM3 1-8U, DSPA2b, IP15 interferon induced transmembrane protein 3 interferon-induced transmembrane protein 3|dispanin subfamily A member 2b|interferon-inducible protein 1-8U
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on IFITM3, check out the IFITM3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for IFITM3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-IFITM3 Antibody (N-term) (M02265-1)
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