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- Table of Contents
Facts about E3 ubiquitin-protein ligase Itchy.
Involved in the management of inflammatory signaling pathways (By similarity). Is an essential element of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways (By similarity).
Mouse | |
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Gene Name: | Itch |
Uniprot: | Q8C863 |
Entrez: | 16396 |
Belongs to: |
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No superfamily |
AIF4; AIP4; AIP4dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4)); atrophin-1 interacting protein 4; Atrophin-1-interacting protein 4; dJ468O1.1; EC 6.3.2; EC 6.3.2.-; ITCH; itchy (mouse homolog) E3 ubiquitin protein ligase; itchy E3 ubiquitin protein ligase homolog (mouse); itchy homolog E3 ubiquitin protein ligase; NAPP1; NAPP1E3 ubiquitin-protein ligase Itchy homolog; NFE2-associated polypeptide 1; ubiquitin protein ligase ITCH
Mass (kDA):
98.994 kDA
Mouse | |
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Location: | 2 H1|2 76.94 cM |
Sequence: | 2; |
Detected in uterus (at protein level) (PubMed:23146885). Widely expressed (PubMed:9462742).
If you are looking for information on Boster's ITCH Marker, you've come to the right place. This article will cover Boster's background, the benefits of this device, and what you should know about the ITCH Marker. Before you purchase the Boster Marker, be sure to read through the Boster Bio: Best Uses Of The ITCH Marker.
Steven Boster's history was a colorful one. During his lifetime, he created more than a thousand products. As a young man, his early research was inspired by a single discovery that he later dubbed as "the lavatory of science." He created different products, including primary antibodies and immunohistochemistry (IHC) kits. By the late 1990s, he had become the biggest catalog antibody company in China. He also developed a proprietary ELISA platform called PicoKine, and used trade secrets to deliver high-sensitivity ELISA kits.
The benefits of the ITCH Marker are numerous. The itch response occurs when a person experiences a sensation of itch, which is transmitted to the cortex through a subset of polymodal fibers that are selective for pruritogens. In addition to the physical and psychological burden they cause, pruritic skin conditions have a high psychological impact. For example, 20% of children in Britain suffer from eczema, and 3% of adults are afflicted with psoriasis. These conditions have a similar psychological impact to chronic pain, as ten percent of patients display clinical depression.
Itchy skin is especially troublesome during sleep, which is when the body is at its highest. The itch response is further amplified during these times of heightened trans-epidermal water loss and circadian skin temperature. Uncontrollable scratching during the night can worsen skin problems and lead to greater inflammation. Additionally, individuals awaken during times when they are unresponsive to the pain of itch. The results of chronic sleep insufficiency are debilitating.
PMID: 9462742 by Perry W.L., et al. The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice.
PMID: 11748237 by Harvey K.F., et al. N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.